μ-Opioid modulation in the rostral solitary nucleus and reticular formation alters taste reactivity: evidence for a suppressive effect on consummatory behavior.
μ-Opioid modulation in the rostral solitary nucleus and reticular formation alters taste reactivity: evidence for a suppressive effect on consummatory behavior.
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头端孤核和网状结构中的μ-阿片类药物调节改变了味觉反应性：对完成行为具有抑制作用的证据。
DOI：
10.1152/ajpregu.00142.2011
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Travers,SusanP
中科院分区：
文献类型：
--
作者：
Kinzeler,NicoleR;Travers,SusanP
摄食的神经控制涉及许多神经调质，包括结合μ-阿片受体（MORs）的内源性阿片类物质。将莫尔激动剂Damgo注射到边缘系统和下丘脑前脑部位增加摄入量，特别是可口食物的摄入量。事实上，前脑Damgo注射增加蔗糖引起的舔，但减少厌恶反应（张口）奎宁，这表明莫尔激活可能会提高味道适口性。尚未在脑干中评估μ-阿片对味觉反应性的影响。然而，MORs存在于一阶味觉中继，孤束的吻侧核（rNST），并立即subjuncular网状结构（RF），一个地区是必不可少的消费反应。因此，为了评估rNST/背侧RF Damgo在该区域的后果，我们在大鼠的rNST的腹侧边缘植入口内插管，肌电图电极和脑插管。舔和张口引起的蔗糖，水，奎宁进行了评估之前和之后髓内Damgo和生理盐水输注。Damgo减慢了速度，增加了幅度，并减少了液体诱导的舔和张口发作的大小。此外，中性刺激水，这通常eleclamps，开始引起gapes。因此，目前的研究结果表明，μ-阿片类激活的rNST/背RF发挥复杂的影响orbital响应，与前脑的影响，更表明抑制，而不是一个促进作用的摄取。
The neural control of feeding involves many neuromodulators, including the endogenous opioids that bind μ-opioid receptors (MORs). Injections of the MOR agonist, Damgo, into limbic and hypothalamic forebrain sites increase intake, particularly of palatable foods. Indeed, forebrain Damgo injections increase sucrose-elicited licking but reduce aversive responding (gaping) to quinine, suggesting that MOR activation may enhance taste palatability. A μ-opioid influence on taste reactivity has not been assessed in the brain stem. However, MORs are present in the first-order taste relay, the rostral nucleus of the solitary tract (rNST), and in the immediately subjacent reticular formation (RF), a region known to be essential for consummatory responses. Thus, to evaluate the consequences of rNST/dorsal RF Damgo in this region, we implanted rats with intraoral cannulas, electromyographic electrodes, and brain cannulas aimed at the ventral border of the rNST. Licking and gaping elicited with sucrose, water, and quinine were assessed before and after intramedullary Damgo and saline infusions. Damgo slowed the rate, increased the amplitude, and decreased the size of fluid-induced lick and gape bouts. In addition, the neutral stimulus water, which typically elicits licks, began to evoke gapes. Thus, the current results demonstrate that μ-opioid activation in the rNST/dorsal RF exerts complex effects on oromotor responding that contrast with forebrain effects and are more indicative of a suppressive, rather than a facilitatory effect on ingestion.
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DOI：
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发表时间：
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