Changes in neuronal activation patterns in response to androgen deprivation therapy: a pilot study.
Changes in neuronal activation patterns in response to androgen deprivation therapy: a pilot study.
复制标题
DOI：
10.1186/1471-2407-10-1
复制
发表时间：
2010-01-04
期刊：
影响因子：
3.8
通讯作者：
Higano CS
中科院分区：
文献类型：
--
作者：
Cherrier MM;Borghesani PR;Shelton AL;Higano CS
男性前列腺癌患者的一种常见治疗选择是雄激素剥夺疗法（ADT）。然而，接受ADT的男性可能会出现身体副作用，生活质量的变化，有时还会出现精神和认知副作用。在这项研究中，没有转移证据且PSA升高的激素初治患者接受了9个月的ADT治疗。在基线治疗前和ADT治疗9个月后，对5名受试者进行了3项视觉空间任务期间的大脑功能磁共振成像（fMRI）。7名健康对照患者在相同的时间间隔接受神经成像。ADT患者在治疗过程中表现出减少的任务相关BOLD-fMRI激活，而对照受试者中未观察到。在回忆物体的空间位置和心理旋转时，观察到右侧顶枕区的激活从基线减少。初步研究结果表明，ADT减少了与心理旋转和准确回忆空间信息有关的大脑区域中与任务相关的神经激活。
A common treatment option for men with prostate cancer is androgen deprivation therapy (ADT). However, men undergoing ADT may experience physical side effects, changes in quality of life and sometimes psychiatric and cognitive side effects. In this study, hormone naïve patients without evidence of metastases with a rising PSA were treated with nine months of ADT. Functional magnetic resonance imaging (fMRI) of the brain during three visuospatial tasks was performed at baseline prior to treatment and after nine months of ADT in five subjects. Seven healthy control patients, underwent neuroimaging at the same time intervals. ADT patients showed reduced, task-related BOLD-fMRI activation during treatment that was not observed in control subjects. Reduction in activation in right parietal-occipital regions from baseline was observed during recall of the spatial location of objects and mental rotation. Findings, while preliminary, suggest that ADT reduces task-related neural activation in brain regions that are involved in mental rotation and accurate recall of spatial information.
登录
查看更多内容
影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
影响因子：
64.8
作者：
Epstein, R;Kanwisher, N
通讯作者：
Kanwisher, N
影响因子：
4.5
作者：
Jenkins, VA;Bloomfield, DJ;Edginton, TL
通讯作者：
Edginton, TL
影响因子：
2.8
作者：
Gizewski, ER;Krause, E;Senf, W
通讯作者：
Senf, W
影响因子：
4.7
作者：
Jacobs, Sheri R.;Jacobsen, Paul B.;Anasetti, Claudio
通讯作者：
Anasetti, Claudio