Chronic discrimination predicts higher circulating levels of E-selectin in a national sample: the MIDUS study.
Chronic discrimination predicts higher circulating levels of E-selectin in a national sample: the MIDUS study.
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DOI：
10.1016/j.bbi.2009.01.002
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发表时间：
2009-07
影响因子：
15.1
通讯作者：
Ryff, Carol D.
中科院分区：
文献类型：
--
作者：
Friedman, Elliot M.;Williams, David R.;Singer, Burton H.;Ryff, Carol D.
少数群体和非少数群体人口中的长期歧视与不良健康后果有关，包括心血管疾病风险增加和死亡率增加，但歧视影响健康的生物过程尚不清楚。目前的研究验证了一个假设，即在白人样本中的歧视将预测血清E-选择素水平升高，这是内皮功能障碍的一个指标，其本身与动脉粥样硬化和心血管疾病的风险有关。来自美国中年调查（MIDUS）的生物标志物样本中的参与者（N = 804）提供了有关主要和日常歧视经历的信息，时间间隔为9 - 10年。歧视措施旨在评估感知的不公平待遇（例如被不公平解雇），而不考虑感知的不公平待遇原因（例如种族、性别）。在第二波数据收集时测定血清E-选择素。女性报告的主要（P <.05）和日常（P <.001）歧视的情况明显多于男性。协方差分析（ANCOVA）显示，终生暴露于主要歧视（P <0.05）和长期暴露于日常歧视（P <0.05）都预示着更高的E-选择素循环水平，但仅限于男性。在调整了潜在的混杂变量（包括年龄、种族、社会经济状况、健康状况和健康行为）后，这些相关性仍然具有统计学意义。这些结果强调了一种潜在的生物学机制，通过这种机制，暴露于不公平的待遇可能与健康，特别是心血管功能有关。此外，越来越多的文献表明，一般来说，不公平的待遇可能会导致不良的健康结果。
Chronic discrimination in both minority and non-minority populations is linked to adverse health outcomes, including increased risk of cardiovascular disease and increased mortality, but the biological processes through which discrimination affects health are unclear. The current study tested the hypothesis that discrimination in a sample of Caucasians would predict elevated serum levels of E-selectin, an indication of endothelial dysfunction which itself is associated with atherosclerosis and cardiovascular disease risk. Participants (N = 804) in the biomarker sample from the Survey of Midlife in the United States (MIDUS) provided information about experiences of both major and everyday discrimination at two times separated by a 9–10 year interval. The discrimination measures were designed to assess perceived unfair treatment (e.g. being fired unfairly) independently of the perceived reasons for the unfair treatment (e.g. race, gender). Serum E-selectin was measured at the second wave of data collection. Women reported significantly more instances of major (P<.05) and everyday P<.001) discrimination than men. Analyses of Covariance (ANCOVA) showed that both greater lifetime exposure to major discrimination (P<.05) and chronic exposure to everyday discrimination (P<.05) predicted higher circulating levels of E-selectin, but only in men. These associations remained statistically significant after adjustments for potential confounding variables, including age, race, socioeconomic status, health status, and health behavior. These results highlight a potential biological mechanism by which exposure to unfair treatment may be related to health, particularly cardiovascular function. Moreover, they add to a growing literature suggesting that unfair treatment in general may predict adverse health outcomes.
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影响因子：
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