First-in-human trial of a novel suprachoroidal retinal prosthesis.
First-in-human trial of a novel suprachoroidal retinal prosthesis.
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DOI：
10.1371/journal.pone.0115239
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Bionic Vision Australia Research Consortium
中科院分区：
文献类型：
--
作者：
Ayton LN;Blamey PJ;Guymer RH;Luu CD;Nayagam DA;Sinclair NC;Shivdasani MN;Yeoh J;McCombe MF;Briggs RJ;Opie NL;Villalobos J;Dimitrov PN;Varsamidis M;Petoe MA;McCarthy CD;Walker JG;Barnes N;Burkitt AN;Williams CE;Shepherd RK;Allen PJ;Bionic Vision Australia Research Consortium
视网膜视觉假体（“仿生眼”）有可能使失明或严重视力受损的患者恢复视力。用于设计、制造和植入此类假体的医学仿生技术仍处于相对初级阶段，各种技术和手术方法正在接受评估。我们假设脉络膜上植入位置（眼睛的巩膜和脉络膜之间）将为患者提供显着的手术和安全益处，使他们能够保持术前残余视力并从设备获得假体视力输入。本报告详细介绍了首次人体 1 期试验，该试验旨在研究三名患有终末期色素性视网膜炎的人类受试者在脉络膜上腔中使用视网膜植入物的情况。脉络膜上腔手术入路的成功及其相关的安全性优势，加上术后 12 个月的疗效数据，为视野恢复带来了希望。临床试验.gov NCT01603576
Retinal visual prostheses (“bionic eyes”) have the potential to restore vision to blind or profoundly vision-impaired patients. The medical bionic technology used to design, manufacture and implant such prostheses is still in its relative infancy, with various technologies and surgical approaches being evaluated. We hypothesised that a suprachoroidal implant location (between the sclera and choroid of the eye) would provide significant surgical and safety benefits for patients, allowing them to maintain preoperative residual vision as well as gaining prosthetic vision input from the device. This report details the first-in-human Phase 1 trial to investigate the use of retinal implants in the suprachoroidal space in three human subjects with end-stage retinitis pigmentosa. The success of the suprachoroidal surgical approach and its associated safety benefits, coupled with twelve-month post-operative efficacy data, holds promise for the field of vision restoration. Clinicaltrials.gov NCT01603576
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DOI：
10.1097/opx.0b013e3182348d0b
发表时间：
2011-12
期刊：
Optometry and vision science : official publication of the American Academy of Optometry
影响因子：
--
作者：
Bittner AK;Ibrahim MA;Haythornthwaite JA;Diener-West M;Dagnelie G
通讯作者：
Dagnelie G
影响因子：
4
作者：
Cicione, Rosemary;Shivdasani, Mohit N.;Williams, Chris E.
通讯作者：
Williams, Chris E.
影响因子：
4
作者：
John, Sam E.;Shivdasani, Mohit N.;Williams, Chris E.
通讯作者：
Williams, Chris E.
影响因子：
4.4
作者：
Hood DC;Lin CE;Lazow MA;Locke KG;Zhang X;Birch DG
通讯作者：
Birch DG
影响因子：
4
作者：
Abramian, Miganoosh;Lovell, Nigel H.;Dokos, Socrates
通讯作者：
Dokos, Socrates