Altered gut microbiomes are associated with the symptomatic status of unruptured intracranial aneurysms.
Altered gut microbiomes are associated with the symptomatic status of unruptured intracranial aneurysms.
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DOI：
10.3389/fnins.2022.1056785
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发表时间：
2022
影响因子：
4.3
通讯作者：
Sun, Haitao
中科院分区：
文献类型：
--
作者：
Sun, Kaijian;Cao, Ying;Chen, Yiting;Peng, Qing;Xie, Yugu;Luo, Yunhao;Tian, Hao;Li, Xin;Zeng, Meiqin;Zhang, Xin;Li, Xifeng;Su, Shixing;He, Xuying;Duan, Chuanzhi;Sun, Haitao
关键词：
Gut microbiome has recently been recognized as an important environmental factor affecting the occurrence and development of unruptured intracranial aneurysms (UIA). This study aimed to investigate the relationship between gut microbiome and symptomatic UIA, which is a predictor of instability and a high propensity to rupture. A total of 132 patients including 86 asymptomatic UIA and 46 symptomatic UIA were recruited in the study. The composition of gut bacterial communities was determined by 16S ribosomal RNA gene sequencing. In addition, Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt) was used to predict the functional composition of the gut microbiome. There is no difference in the fecal microbial alpha diversity between symptomatic and asymptomatic UIA, but gut microbiome composition changed significantly. At the order level, the relative abundance of Clostridiales was significantly enriched in the symptomatic compared with asymptomatic UIA (p = 0.043). In addition, similar alterations were observed at the family levels of Ruminococcaceae. The Linear discriminant analysis (LEfSe) revealed Fournierella, Ruthenibacterium, and Anaerotruncus as discriminative features in the symptomatic group. Notably, functional differences in gut microbiome of patients with symptomatic UIA included decreased propionate metabolism pathway and enrichment of peptidoglycan biosynthesis pathways. The present study comprehensively characterizes gut microbiome in a large cohort of different risk statuses of UIA patients and demonstrates the potential biological function of gut microbiome involved in the development of UIA. It may provide additional benefits in guiding UIA management and improving patient outcomes.
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影响因子：
3.5
作者：
Hwang N;Eom T;Gupta SK;Jeong SY;Jeong DY;Kim YS;Lee JH;Sadowsky MJ;Unno T
通讯作者：
Unno T
影响因子：
8.3
作者：
Jabbarli, Ramazan;Dinger, Thiemo Florin;Sure, Ulrich
通讯作者：
Sure, Ulrich
影响因子：
56.9
作者：
Gabanyi, Ilana;Lepousez, Gabriel;Lledo, Pierre-Marie
通讯作者：
Lledo, Pierre-Marie
影响因子：
4.1
作者：
Nakagawa D;Kudo K;Awe O;Zanaty M;Nagahama Y;Cushing C;Magnotta V;Hayakawa M;Allan L;Greenlee J;Awad IA;Carroll T;Torner J;Raghavan ML;Hasan DM
通讯作者：
Hasan DM
影响因子：
8.3
作者：
Kawabata, Shuhei;Takagaki, Masatoshi;Kishima, Haruhiko
通讯作者：
Kishima, Haruhiko