Is exercise a senolytic medicine? A systematic review.
Is exercise a senolytic medicine? A systematic review.
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DOI：
10.1111/acel.13294
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发表时间：
2021-01
期刊：
影响因子：
7.8
通讯作者：
Chang RC
中科院分区：
文献类型：
--
作者：
Chen XK;Yi ZN;Wong GT;Hasan KMM;Kwan JS;Ma AC;Chang RC
细胞衰老是由各种应激因素引发的不可逆的生长停滞状态，参与一类病理过程，其中衰老细胞在有丝分裂组织中积累。抗衰老药物是近年来迅速发展起来的一种通过清除衰老细胞来抗衰老和各种疾病的新药。运动是一种有效的抗衰老和抗慢性疾病药物，在过去的十年中，它已经显示出降低细胞衰老标志物的能力。然而，运动是否是衰老和各种疾病的衰老药物仍不清楚。在这里，我们已经进行了系统的文献综述，研究在人类和动物模型的各种状态下，运动或体力活动对衰老细胞的衰老作用。运动可以减少健康人的衰老细胞标志物，而运动可以降低肥胖但不健康动物的衰老细胞标志物。人类和动物研究之间的差异可能是由于研究量相对较小以及衰老细胞标记物、细胞/组织类型和健康状况的变化。这些发现表明，运动在一定条件下具有衰老清除作用，值得进一步研究。细胞衰老上调某些标志物，如p16 INK 4a，p21 Cip 1，SA-β-Gal和/或SASP，这也可以在加速老化的动物中显示。这篇综述讨论了通过使用人类和实验室动物研究，以显示如何运动衰减所有这些衰老标记物，并作为衰老药物。
Cellular senescence, a state of irreversible growth arrest triggered by various stressors, engages in a category of pathological processes, whereby senescent cells accumulate in mitotic tissues. Senolytics as novel medicine against aging and various diseases through the elimination of senescent cells has emerged rapidly in recent years. Exercise is a potent anti‐aging and anti‐chronic disease medicine, which has shown the capacity to lower the markers of cellular senescence over the past decade. However, whether exercise is a senolytic medicine for aging and various diseases remains unclear. Here, we have conducted a systematic review of the published literature studying the senolytic effects of exercise or physical activity on senescent cells under various states in both human and animal models. Exercise can reduce the markers of senescent cells in healthy humans, while it lowered the markers of senescent cells in obese but not healthy animals. The discrepancy between human and animal studies may be due to the relatively small volume of research and the variations in markers of senescent cells, types of cells/tissues, and health conditions. These findings suggest that exercise has senolytic properties under certain conditions, which warrant further investigations. Cellular senescent upregulates certain markers such as p16INK4a, p21Cip1, SA‐beta‐Gal, and/or SASP, which can also be shown in accelerated aging animals. This review discusses by using human and experimental laboratory animal studies to show how exercise attenuates all these senescent markers and serves as senolytic medicine.
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影响因子：
7.4
作者：
Gomez-Cabrera, Mari-Carmen;Domenech, Elena;Vina, Jose
通讯作者：
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影响因子：
5.2
作者：
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影响因子：
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作者：
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DOI：
10.1155/2013/275431
发表时间：
2013
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Huang CC;Chiang WD;Huang WC;Huang CY;Hsu MC;Lin WT
通讯作者：
Lin WT
影响因子：
11.1
作者：
Justice, Jamie N.;Nambiar, Anoop M.;Kirkland, James L.
通讯作者：
Kirkland, James L.