Toll like receptor7 polymorphisms in relation to disease susceptibility and progression in Chinese patients with chronic HBV infection.
Toll like receptor7 polymorphisms in relation to disease susceptibility and progression in Chinese patients with chronic HBV infection.
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Toll样受体7多态性与中国慢性乙型肝炎患者疾病易感性和进展的关系
DOI：
10.1038/s41598-017-12698-5
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发表时间：
2017-09-29
影响因子：
4.6
通讯作者：
He Q
中科院分区：
文献类型：
--
作者：
Zhu J;Zhang T;Cao L;Li A;Zheng K;Zhang N;Su B;Chen Z;Chen N;Wu H;He Q
Toll样受体（TLR）在先天性和适应性免疫中起关键作用，保护宿主免受病毒病原体的侵害。我们研究了TLR 7基因多态性对中国成年人慢性B型肝炎（CH B）感染疾病易感性和进展的影响。从612例确诊为慢性B型肝炎、B型肝炎病毒（HBV）相关肝硬化（LC）或肝细胞癌（HCC）的患者和293例对照组中采集血样。通过PCR测序分析TLR 7多态性（rs 179010-C > T、rs 2074109-T > C和rs 179009-A > G）。男性CHB患者TLR 7 rs 179010 C等位基因频率显著高于对照组（74.8%vs59.5%，P = 0.002）。男性CHB、LC和HCC患者中rs 179009 G等位基因频率随疾病进展而显著增加（P = 0.012）。男性患者中，单倍型CTA与CHB易感性增加显著相关（P = 0.000）。男性HCC患者CTG单倍型频率高于CHB患者（P = 0.005）。在女性患者和对照组之间没有发现这些等位基因频率的差异。结果表明，TLR 7基因多态性在中国成年人慢性乙型肝炎的易感性和进展中起重要作用，并可能部分解释中国男性HBV相关疾病的高发性。
Toll-like receptors (TLRs) play a key role in innate and adaptive immunity, protecting the host from viral pathogens. We studied the effect of TLR7 polymorphisms on disease susceptibility and progression of chronic hepatitis B (CHB) infection in Chinese adults. Blood samples were taken from 612 patients with confirmed CHB, hepatitis B virus (HBV)-related liver cirrhosis (LC) or hepatocellular carcinoma (HCC) and 293 controls. TLR7 polymorphisms (rs179010-C > T, rs2074109-T > C, and rs179009-A > G) were analyzed by PCR-based sequencing. A significantly higher frequency of TLR7 rs179010 C allele was found in male CHB patients than in controls (74.8% vs 59.5%, P = 0.002). The frequency of rs179009 G allele was markedly increased with disease progression when male patients with CHB, LC and HCC were compared (P = 0.012). The haplotype CTA was significantly associated with an increased susceptibility to CHB among male patients (P = 0.000). Frequency of the haplotype CTG was higher in male patients with HCC than CHB (P = 0.005). No such differences in these allele frequencies were found between female patients and controls. Our results indicated that TLR7 polymorphisms play an important role in disease susceptibility and the progression of CHB infections in Chinese adults, and may partly explain the high incidence of HBV related diseases in Chinese men.
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影响因子：
4.9
作者：
Kawasaki A;Furukawa H;Kondo Y;Ito S;Hayashi T;Kusaoi M;Matsumoto I;Tohma S;Takasaki Y;Hashimoto H;Sumida T;Tsuchiya N
通讯作者：
Tsuchiya N
GS-9620是Toll样受体-7的口服激动剂，可长期抑制慢性感染的黑猩猩的丙型肝炎病毒。
影响因子：
29.4
作者：
Lanford RE;Guerra B;Chavez D;Giavedoni L;Hodara VL;Brasky KM;Fosdick A;Frey CR;Zheng J;Wolfgang G;Halcomb RL;Tumas DB
通讯作者：
Tumas DB
DOI：
10.1038/nri2394
发表时间：
2008-09
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Fish EN
通讯作者：
Fish EN
DOI：
10.1038/nri3151
发表时间：
2012-02-03
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
影响因子：
168.9
作者：
Lozano, Rafael;Naghavi, Mohsen;Murray, Christopher J. L.
通讯作者：
Murray, Christopher J. L.