Astragaloside IV alleviates early brain injury following experimental subarachnoid hemorrhage in rats.
Astragaloside IV alleviates early brain injury following experimental subarachnoid hemorrhage in rats.
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黄芪甲苷 IV 可减轻大鼠实验性蛛网膜下腔出血后的早期脑损伤
DOI：
10.7150/ijms.9282
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发表时间：
2014
影响因子：
3.6
通讯作者：
Zhang J
中科院分区：
文献类型：
--
作者：
Shao A;Guo S;Tu S;Ammar AB;Tang J;Hong Y;Wu H;Zhang J
黄芪皂苷IV是黄芪的主要有效成分之一，具有多种神经保护作用，但其对蛛网膜下腔出血(SAH)所致早期脑损伤(EBI)的保护作用及其可能机制尚不清楚。本研究旨在探讨黄芪甲苷能否抑制实验性蛛网膜下腔出血后大鼠的氧化应激，减少神经细胞凋亡，改善神经功能缺失。将68只大鼠随机分为假手术组、SAH组、SAH+赋形剂组和SAH+黄芪甲苷IV组。SAH后1h、6h给予黄芪甲苷或等量溶媒，于SAH后24h处死大鼠。对死亡率、神经学评分和脑水肿进行了评估，同时进行了生化测试和组织学研究。SAH可导致脑组织丙二醛(MDA)水平升高、神经细胞凋亡、caspase3裂解、脑水肿、超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)活性降低。黄芪甲苷治疗逆转了这些变化，并改善了SAH大鼠的神经行为结果。我们的研究结果提示黄芪甲苷可能通过抗氧化和抗细胞凋亡的作用减轻SAH后的EBI。
Astragaloside IV, one of the main effective components isolated from Astragalus membranaceus, has multiple neuroprotective properties, while the effects of astragaloside IV on the attenuation of subarachnoid hemorrhage (SAH)-induced early brain injury (EBI) and its possible mechanisms are unknown. In the present study, we aimed to determine whether astragaloside IV could inhibit oxidative stress, reduce neuronal apoptosis, and improve neurological deficits after experimental SAH in rats. Rats (n=68) were randomly divided into the following groups: Sham group, SAH group, SAH+vehicle group, and SAH+astragaloside IV group. Astragaloside IV or an equal volume of vehicle was administered at 1 h and 6 h after SAH, all the rats were subsequently sacrificed at 24 h after SAH. Mortality, neurological scores, and brain edema were assessed, biochemical tests and histological studies were also performed at that point. SAH induced an increase in the malondialdehyde (MDA) level, neuronal apoptosis, cleaved caspase 3, brain edema and decreased activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). Astragaloside IV treatment reversed these changes and improved neurobehavioral outcomes of SAH rats. Our findings suggested that astragaloside IV may alleviate EBI after SAH through antioxidative and anti-apoptotic effects.
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影响因子：
8.8
作者：
Altay O;Hasegawa Y;Sherchan P;Suzuki H;Khatibi NH;Tang J;Zhang JH
通讯作者：
Zhang JH
影响因子：
6.3
作者：
Endo, Hidenori;Nito, Chikako;Chan, Pak H.
通讯作者：
Chan, Pak H.
影响因子：
7.4
作者：
Li, Xiaoming;Wang, Xiaoli;Niu, Yingcai
通讯作者：
Niu, Yingcai
影响因子：
8.3
作者：
Altay O;Suzuki H;Hasegawa Y;Caner B;Krafft PR;Fujii M;Tang J;Zhang JH
通讯作者：
Zhang JH
影响因子：
2.7
作者：
Hong F;Xiao W;Ragupathi G;Lau CB;Leung PC;Yeung KS;George C;Cassileth B;Kennelly E;Livingston PO
通讯作者：
Livingston PO