Interspecific nematode signals regulate dispersal behavior.
Interspecific nematode signals regulate dispersal behavior.
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DOI：
10.1371/journal.pone.0038735
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Teal PE
中科院分区：
文献类型：
--
作者：
Kaplan F;Alborn HT;von Reuss SH;Ajredini R;Ali JG;Akyazi F;Stelinski LL;Edison AS;Schroeder FC;Teal PE
扩散是线虫的一种重要行为。在拥挤或食物耗尽时，自由生活的食菌线虫秀丽隐杆线虫产生抗胁迫的散布幼虫，称为dauer，其类似于植物寄生的根结线虫属的第二阶段幼虫（J2）。和昆虫病原线虫（EPN）的感染性幼虫（IJ），例如，斯氏线虫对C.线虫或任何其他线虫物种。基于子囊苷对幼叶期进入的调控以及对C.线虫成虫的扩散行为包括交配、回避和聚集等，我们推测蛔虫素可能也参与了线虫扩散行为的调节。elegans和其他线虫，如IJ的线虫相关的EPN。液相色谱-质谱联用技术分析C.显示出强分散活性的ElegansDauer条件培养基显示出四种已知的子囊苷（ASCR#2、ASCR#3、ASCR#8、ICAS#9）。将这些Ascarosides在生理相关浓度下的合成共混物分散在C. elegans dauer在食物存在的情况下，也引起了S. feltiae和J2 s。分析指导的分级显示结构类似物作为S. feltiae（ascr#9）和C. elegans（ascr#2）分散共混物。进一步分析显示所有斯氏线虫属中的ascr#9。和异小杆线虫属（Heterorhabditis spp.）感染的昆虫宿主尸体Ascaroside共混物代表了进化上保守的，从根本上重要的通信系统，线虫从不同的栖息地，因此可能提供可持续的手段控制寄生线虫。
Dispersal is an important nematode behavior. Upon crowding or food depletion, the free living bacteriovorus nematode Caenorhabditis elegans produces stress resistant dispersal larvae, called dauer, which are analogous to second stage juveniles (J2) of plant parasitic Meloidogyne spp. and infective juveniles (IJ)s of entomopathogenic nematodes (EPN), e.g., Steinernema feltiae. Regulation of dispersal behavior has not been thoroughly investigated for C. elegans or any other nematode species. Based on the fact that ascarosides regulate entry in dauer stage as well as multiple behaviors in C. elegans adults including mating, avoidance and aggregation, we hypothesized that ascarosides might also be involved in regulation of dispersal behavior in C. elegans and for other nematodes such as IJ of phylogenetically related EPNs. Liquid chromatography-mass spectrometry analysis of C. elegans dauer conditioned media, which shows strong dispersing activity, revealed four known ascarosides (ascr#2, ascr#3, ascr#8, icas#9). A synthetic blend of these ascarosides at physiologically relevant concentrations dispersed C. elegans dauer in the presence of food and also caused dispersion of IJs of S. feltiae and J2s of plant parasitic Meloidogyne spp. Assay guided fractionation revealed structural analogs as major active components of the S. feltiae (ascr#9) and C. elegans (ascr#2) dispersal blends. Further analysis revealed ascr#9 in all Steinernema spp. and Heterorhabditis spp. infected insect host cadavers. Ascaroside blends represent evolutionarily conserved, fundamentally important communication systems for nematodes from diverse habitats, and thus may provide sustainable means for control of parasitic nematodes.
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比较代谢组学揭示了丙烷剂的生物发生，这是秀丽隐杆线虫中小分子信号的模块化库。
影响因子：
15
作者：
von Reuss, Stephan H.;Bose, Neelanjan;Srinivasan, Jagan;Yim, Joshua J.;Judkins, Joshua C.;Sternberg, Paul W.;Schroeder, Frank C.
通讯作者：
Schroeder, Frank C.
DOI：
10.1098/rspb.2003.2647
发表时间：
2004-04-22
影响因子：
4.7
作者：
Symonds, MRE;Elgar, MA
通讯作者：
Elgar, MA
影响因子：
1.2
作者：
Brito, Janete A.;Kaur, Ramandeep;Dickson, Donald W.
通讯作者：
Dickson, Donald W.
影响因子：
56.9
作者：
GOLDEN, JW;RIDDLE, DL
通讯作者：
RIDDLE, DL
影响因子：
64.8
作者：
Jeong, PY;Jung, M;Paik, YK
通讯作者：
Paik, YK