Recent advances in humanized mice: accelerating the development of an HIV vaccine.
Recent advances in humanized mice: accelerating the development of an HIV vaccine.
复制标题
人源化小鼠的最新进展：加速艾滋病毒疫苗的开发。
DOI：
10.1093/infdis/jit451
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Allen,ToddM
中科院分区：
文献类型：
--
作者：
Tager,AndrewM;Pensiero,Michael;Allen,ToddM
Recent advances in the development of humanized mice hold great promise to advance our understanding of protective immunity to human immunodeficiency virus (HIV) infection and to aid in the design of an effective HIV vaccine. This supplement of theJournal of Infectious Diseasessummarizes work in the humanized mouse model presented at an HIV Humanized Mouse workshop in Boston, Massachusetts, in November 2012, including recent advances in the development of humanized mice, the trafficking of human immune cells following mucosal HIV transmission, the role of immune activation and Toll-like receptor agonists in the control of HIV, the induction and efficacy of HIV-specific cellular and humoral immune responses, and the preclinical modeling of novel anti-HIV therapeutics. Many gaps remain in our understanding of how to design an effective HIV vaccine and novel therapeutics to eliminate the viral reservoir. Promising early results from studies in humanized mice suggest great potential and enthusiasm for this model to accelerate these critical areas of HIV research.
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DOI：
10.1056/nejmoa1113425
发表时间：
2012-04-05
期刊：
The New England journal of medicine
影响因子：
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