Binocular Integrated Visual Field Deficits Are Associated With Changes in Local Network Function in Primary Open-Angle Glaucoma: A Resting-State fMRI Study.
Binocular Integrated Visual Field Deficits Are Associated With Changes in Local Network Function in Primary Open-Angle Glaucoma: A Resting-State fMRI Study.
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DOI：
10.3389/fnagi.2021.744139
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发表时间：
2021
影响因子：
4.8
通讯作者：
Cornelissen FW
中科院分区：
文献类型：
--
作者：
Demaria G;Invernizzi A;Ombelet D;Carvalho JC;Renken RJ;Cornelissen FW
在青光眼参与者中，已经观察到大脑结构和功能的变化，但我们对这些变化如何影响皮质功能网络的完整性以及这些变化如何与视觉功能相关仍然了解不足。这是相关的，因为功能网络的完整性可能会影响未来治疗的适用性，以及康复或训练的选择。在这里，我们比较了青光眼参与者和对照组之间局部和局部大脑网络的整体和局部功能连接。此外，我们还研究了功能连通性与视野（VF）丧失之间的关系。在我们的研究中，我们招募了20名原发性开角型青光眼（POAG）患者和24名年龄相似的健康参与者进行眼科评估，然后进行两次静息状态（RS） (f)MRI扫描。对于每一次扫描和每一组，特征向量中心性（EC）值高于第95百分位的roi被认为是最中央的大脑区域（“枢纽”）。我们在青光眼和健康参与者之间的两次扫描中发现EC显著差异的中心被认为提供了网络变化的证据。此外，我们测试了一个概念，即POAG大脑区域的中枢功能可能与参与者的VF缺陷的严重程度有关，而不管哪只眼睛是主要原因。为了确定这一点，对于每个参与者，得出了与眼睛无关的分数：(1)较差的眼睛的灵敏度-表明疾病的严重程度，(2)两只眼睛的灵敏度-一只眼睛可能补偿另一只眼睛的损失，或(3)眼睛灵敏度的差异-可能需要额外的网络相互作用。通过将这些VF分数和EC值相关联，我们评估了VF缺陷是否与POAG的中心性改变有关。我们的研究结果表明，POAG参与者在整个大脑水平上没有发现功能性连接中断。这表明在青光眼中，全球脑网络通信得以保留。此外，对于被确定为大脑中枢的舌回，我们发现EC值与双眼的VF灵敏度之间存在正相关关系。局部网络功能的降低与双目VF敏感度的降低有关，这一事实表明，局部大脑重组的存在与功能性视觉能力有关。
In glaucoma participants, both structural and functional brain changes have been observed, but we still have insufficient understanding of how these changes also affect the integrity of cortical functional networks, and how these changes relate to visual function. This is relevant, as functional network integrity may affect the applicability of future treatments, as well as the options for rehabilitation or training. Here, we compare global and local functional connectivity in local and global brain networks between glaucoma and control participants. Moreover, we study the relationship between functional connectivity and visual field (VF) loss. For our study, 20 subjects with primary open-angle glaucoma (POAG) and 24 age-similar healthy participants were recruited to undergo an ophthalmic assessment followed by two resting-state (RS) (f)MRI scans. For each scan and for each group, the ROIs with eigenvector centrality (EC) values higher than the 95th percentile were considered the most central brain regions (“hubs”). Hubs for which we found a significant difference in EC in both scans between glaucoma and healthy participants were considered to provide evidence for network changes. In addition, we tested the notion that a brain region's hub function in POAG might relate to the severity of a participant's VF defect, irrespective of which eye contributed mostly to this. To determine this, for each participant, eye-independent scores were derived for: (1) sensitivity of the worse eye – indicating disease severity, (2) sensitivity of both eyes combined – with one eye potentially compensating for loss in the other, or (3) difference in eye sensitivity – potentially requiring additional network interactions. By correlating each of these VF scores and the EC values, we assessed whether VF defects could be associated with centrality alterations in POAG. Our results show that no functional connectivity disruptions were found at the global brain level in POAG participants. This indicates that in glaucoma global brain network communication is preserved. Furthermore, for the Lingual Gyrus, identified as a brain hub, we found a positive correlation between the EC value and the VF sensitivity of both eyes combined. The fact that reduced local network functioning is associated with reduced binocular VF sensitivity suggests the presence of local brain reorganization that has a bearing on functional visual abilities.
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影响因子：
1.6
作者：
Jiang MM;Zhou Q;Liu XY;Shi CZ;Chen J;Huang XH
通讯作者：
Huang XH
DOI：
10.1007/s00417-004-0984-x
发表时间：
2005-03-01
影响因子：
2.7
作者：
Crabb, DP;Viswanathan, AC
通讯作者：
Viswanathan, AC
影响因子：
2.9
作者：
Haykal S;Jansonius NM;Cornelissen FW
通讯作者：
Cornelissen FW
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影响因子：
4.8
作者：
Dai, Hui;Morelli, John N.;Li, Yonggang
通讯作者：
Li, Yonggang
影响因子：
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作者：
Pruim, Raimon H. R.;Mennes, Maarten;Beckmann, Christian F.
通讯作者：
Beckmann, Christian F.