Hyperglycemia-induced oxidative stress and heart disease-cardioprotective effects of rooibos flavonoids and phenylpyruvic acid-2-O-β-D-glucoside.
Hyperglycemia-induced oxidative stress and heart disease-cardioprotective effects of rooibos flavonoids and phenylpyruvic acid-2-O-β-D-glucoside.
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DOI：
10.1186/s12986-017-0200-8
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发表时间：
2017
影响因子：
4.5
通讯作者：
Johnson R
中科院分区：
文献类型：
--
作者：
Dludla PV;Joubert E;Muller CJF;Louw J;Johnson R
与非糖尿病患者相比，糖尿病患者发生心力衰竭的风险更高。累积的证据表明，慢性高血糖是这些患者发生心肌梗塞的核心。目前，旨在专门保护处于高血糖引起损伤风险的糖尿病心脏的治疗方法有限。据推测，氧化应激通过自由基种类的过度产生来改变线粒体功能并异常增强 NADPH 氧化酶系统的活性，从而导致糖尿病状态下加速心肌损伤。这导致人们对已知具有抗氧化特性的植物源材料的探索急剧增加。几种可食用植物含有多种天然成分，包括多酚，它们可以通过细胞内信号通路的调节作用来抵消氧化引起的组织损伤。路易波士茶是一种南非本土植物，因其用作花草茶而闻名，人们越来越多地研究其代谢益处。将富含路易波士多酚的饮食与减少糖尿病相关心血管并发症联系起来的前瞻性研究尚未得到广泛评估。阿斯帕拉丁（一种类黄酮）和苯丙酮酸-2-O-β-D-葡萄糖苷（一种酚类前体）是路易波士茶中发现的一些主要化合物，可以在体外改善高血糖引起的心肌细胞损伤。虽然后者已被证明具有防止细胞凋亡的潜力，但阿帕拉丁的拟议作用机制与其增强核因子（红细胞衍生 2）样 2 (Nrf2) 表达（一种细胞内抗氧化反应元件）的能力有关。因此，我们在此回顾了有关路易波士茶中黄酮类化合物和苯丙烯酸对糖尿病引起的氧化损伤的潜在心脏保护作用的文献。
Diabetic patients are at an increased risk of developing heart failure when compared to their non-diabetic counter parts. Accumulative evidence suggests chronic hyperglycemia to be central in the development of myocardial infarction in these patients. At present, there are limited therapies aimed at specifically protecting the diabetic heart at risk from hyperglycemia-induced injury. Oxidative stress, through over production of free radical species, has been hypothesized to alter mitochondrial function and abnormally augment the activity of the NADPH oxidase enzyme system resulting in accelerated myocardial injury within a diabetic state. This has led to a dramatic increase in the exploration of plant-derived materials known to possess antioxidative properties. Several edible plants contain various natural constituents, including polyphenols that may counteract oxidative-induced tissue damage through their modulatory effects of intracellular signaling pathways. Rooibos, an indigenous South African plant, well-known for its use as herbal tea, is increasingly studied for its metabolic benefits. Prospective studies linking diet rich in polyphenols from rooibos to reduced diabetes associated cardiovascular complications have not been extensively assessed. Aspalathin, a flavonoid, and phenylpyruvic acid-2-O-β-D-glucoside, a phenolic precursor, are some of the major compounds found in rooibos that can ameliorate hyperglycemia-induced cardiomyocyte damage in vitro. While the latter has demonstrated potential to protect against cell apoptosis, the proposed mechanism of action of aspalathin is linked to its capacity to enhance the expression of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) expression, an intracellular antioxidant response element. Thus, here we review literature on the potential cardioprotective properties of flavonoids and a phenylpropenoic acid found in rooibos against diabetes-induced oxidative injury.
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DOI：
10.1016/j.bbrc.2008.06.077
发表时间：
2008-09-05
影响因子：
3.1
作者：
Ahn, Jiyun;Lee, Hyunjung;Ha, Taleyoul
通讯作者：
Ha, Taleyoul
影响因子：
1.4
作者：
Baba, Haruna;Ohtsuka, Yoshikazu;Shimizu, Toshiaki
通讯作者：
Shimizu, Toshiaki
影响因子：
5
作者：
Baines, Christopher P.
通讯作者：
Baines, Christopher P.
影响因子：
8.2
作者：
Boudina, Sihem;Abel, Evan Dale
通讯作者：
Abel, Evan Dale
影响因子：
3.7
作者：
Bian C;Xu T;Zhu H;Pan D;Liu Y;Luo Y;Wu P;Li D
通讯作者：
Li D