Size control during organogenesis: Development of the lateral line organs in zebrafish

Size control during organogenesis: Development of the lateral line organs in zebrafish
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器官发生过程中的大小控制:斑马鱼侧线器官的发育

DOI:
10.1111/dgd.12196
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发表时间:
2015
期刊:
Development, Growth and Differentiation
影响因子:
--
通讯作者:
K.
K.
中科院分区:
--
文献类型:
--
作者:
Wada;H. and Kawakami;K.

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许多在器官生长中起重要作用的基因已经在一系列生物体中被鉴定出来。然而,生长器官能够感知其大小并在达到适当大小时停止生长的机制仍然知之甚少。鱼类侧线系统的机械感觉器官(神经乳突)提供了一个理想的系统来解决这个问题,原因如下。首先,每个浅表神经肥大由位于体表的少量细胞组成,使得在整个发育过程中量化器官大小相对容易。其次,虽然表面神经瘤的感觉细胞不断更新,但整体器官大小保持稳态。第三,还有另一种类型的神经肥大显示出相反的生长模式:即,神经管神经肥大的大小与生物体的大小成比例地增加。在这里,我们回顾了最近的研究结果有关的机制,控制器官的大小在斑马鱼侧线。
Many genes that play essential roles in organ growth have been identified across a range of organisms. However, the mechanisms by which growing organs can sense their sizes and stop growing when they reach their proper sizes remain poorly understood. The mechanosensory organs of the fish lateral line system (neuromasts) provide an ideal system to address this question for the following reasons. First, each superficial neuromast is composed of a small number of cells situated on the body surface, making it relatively easy to quantify organ size throughout development. Second, while the sensory cells of superficial neuromasts are continuously renewed, overall organ size is homeostatically maintained. Third, there is another type of neuromast showing an opposite mode of growth: that is, canal neuromasts increase in size in proportion to organism body size. Here, we review recent findings regarding the mechanisms that control organ size in the zebrafish lateral line.
DOI: 10.1002/jez.1400760203
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影响因子: --
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