A pH-activatable and aniline-substituted photosensitizer for near-infrared cancer theranostics.
A pH-activatable and aniline-substituted photosensitizer for near-infrared cancer theranostics.
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用于近红外癌症治疗诊断的 pH 可激活苯胺取代光敏剂
DOI：
10.1039/c5sc01721a
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发表时间：
2015-10-01
期刊：
影响因子：
8.4
通讯作者：
Ju H
中科院分区：
文献类型：
--
作者：
Tian J;Zhou J;Shen Z;Ding L;Yu JS;Ju H
设计了一种三功能光敏剂，以实现高选择性的近红外肿瘤成像，高效的光动力学治疗和治疗自我监测。本工作报告了一种新设计的pH可激活和苯胺取代的氮杂硼二吡咯亚甲基作为三功能光敏剂，通过封装在cRGD功能化纳米胶束中实现高度选择性的肿瘤成像，有效的光动力学治疗（PDT）和治疗自我监测。二乙氨基苯基被引入到结构中用于pH可激活的近红外荧光和单线态氧（1O2）产生，并且溴苯基被引入以借助于其重原子效应在pH激活时增加1O2产生效率。包封后，纳米探针可以通过cRGD靶向富含αvβ3整联蛋白的肿瘤细胞，并通过生理酸性pH激活，用于癌症识别和PDT。纳米探针的迷人优势是超过800 nm的近红外实现，这显著提高了成像灵敏度并增加了PDT的穿透深度。通过监测PDT治疗后肿瘤区域的荧光衰减情况，原位、真实的实时地展示治疗效果，为PDT疗效跟踪提供了一种有价值的、方便的自反馈功能。因此，这种合理设计和精心设计的纳米探针为精确的肿瘤治疗诊断提供了新的范例，并可能为未来的临床癌症治疗提供新的机会。
A trifunctional photosensitizer was designed to achieve highly selective near-infrared tumor imaging, efficient photodynamic therapy and therapeutic self-monitoring. This work reports a newly designed pH-activatable and aniline-substituted aza-boron-dipyrromethene as a trifunctional photosensitizer to achieve highly selective tumor imaging, efficient photodynamic therapy (PDT) and therapeutic self-monitoring through encapsulation in a cRGD-functionalized nanomicelle. The diethylaminophenyl is introduced in to the structure for pH-activatable near-infrared fluorescence and singlet oxygen (1O2) generation, and bromophenyl is imported to increase the 1O2 generation efficiency upon pH activation by virtue of its heavy atom effect. After encapsulation, the nanoprobe can target αvβ3 integrin-rich tumor cells via cRGD and is activated by physiologically acidic pH for cancer discrimination and PDT. The fascinating advantage of the nanoprobe is near-infrared implementation beyond 800 nm, which significantly improves the imaging sensitivity and increases the penetration depth of the PDT. By monitoring the fluorescence decrease in the tumor region after PDT, the therapeutic efficacy is demonstrated in situ and in real time, which provides a valuable and convenient self-feedback function for PDT efficacy tracking. Therefore, this rationally designed and carefully engineered nanoprobe offers a new paradigm for precise tumor theranostics and may provide novel opportunities for future clinical cancer treatment.
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影响因子：
4.9
作者：
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