Genetic and environmental factors affecting cryptic variations in gene regulatory networks.
Genetic and environmental factors affecting cryptic variations in gene regulatory networks.
复制标题
DOI：
10.1186/1471-2148-13-91
复制
发表时间：
2013-04-26
影响因子：
3.4
通讯作者：
Kawata M
中科院分区：
文献类型：
--
作者：
Iwasaki WM;Tsuda ME;Kawata M
隐性遗传变异（CGV）被认为通过响应内部和/或外部环境的变化产生可见的变异来促进表型进化。已经提出了几种能够使CGV积累和释放的机制。在这项研究中，我们专注于基因调控网络（GRNs）作为产生CGV的重要机制，并研究了GRNs和环境之间的相互作用如何通过使用基于个体的模拟来影响CGV的数量。允许GRNs群体在各种稳定选择下进化，然后我们测量了出现的遗传和表型变异的数量。我们的研究结果表明，CGV没有耗尽的强度稳定选择每个表型，而在人口中的遗传变异的可见部分随着选择强度的增加而减少。另一方面，增加个人一生中遇到的不同环境的数量（即，导致对多种环境的可塑性反应）抑制了CGV的积累，而具有更多基因和相互作用的GRNs在这种异质性环境中受到青睐。鉴于研究结果表明，在人口中的CGV的数量在很大程度上是由GRNs的大小（顺序），我们建议，扩大GRNs和适应新的环境是相互促进和可持续的来源的进化，因此生物多样性和复杂性的起源。
Cryptic genetic variation (CGV) is considered to facilitate phenotypic evolution by producing visible variations in response to changes in the internal and/or external environment. Several mechanisms enabling the accumulation and release of CGVs have been proposed. In this study, we focused on gene regulatory networks (GRNs) as an important mechanism for producing CGVs, and examined how interactions between GRNs and the environment influence the number of CGVs by using individual-based simulations. Populations of GRNs were allowed to evolve under various stabilizing selections, and we then measured the number of genetic and phenotypic variations that had arisen. Our results showed that CGVs were not depleted irrespective of the strength of the stabilizing selection for each phenotype, whereas the visible fraction of genetic variation in a population decreased with increasing strength of selection. On the other hand, increasing the number of different environments that individuals encountered within their lifetime (i.e., entailing plastic responses to multiple environments) suppressed the accumulation of CGVs, whereas the GRNs with more genes and interactions were favored in such heterogeneous environments. Given the findings that the number of CGVs in a population was largely determined by the size (order) of GRNs, we propose that expansion of GRNs and adaptation to novel environments are mutually facilitating and sustainable sources of evolvability and hence the origins of biological diversity and complexity.
登录
查看更多内容
影响因子：
30.8
作者：
Carlborg, Ö;Jacobsson, L;Andersson, L
通讯作者：
Andersson, L
影响因子：
0.9
作者：
Guo, Wenge;Rao, M. Bhaskara
通讯作者：
Rao, M. Bhaskara
影响因子：
2.3
作者：
Dudley, J. W.
通讯作者：
Dudley, J. W.
影响因子：
3.4
作者：
Espinosa-Soto C;Martin OC;Wagner A
通讯作者：
Wagner A
影响因子：
3.3
作者：
Gjuvsland, Arne B.;Hayes, Ben J.;Carlborg, Orjan
通讯作者：
Carlborg, Orjan