Phenotypic plasticity can facilitate adaptive evolution in gene regulatory circuits.
Phenotypic plasticity can facilitate adaptive evolution in gene regulatory circuits.
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DOI：
10.1186/1471-2148-11-5
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发表时间：
2011-01-06
影响因子：
3.4
通讯作者：
Wagner A
中科院分区：
文献类型：
--
作者：
Espinosa-Soto C;Martin OC;Wagner A
许多重要的进化适应源于基因调控回路的修改以产生新的基因活性表型。不断进化的群体如何筛选天文数字的回路来寻找具有新的适应性表型的回路？答案可能常常涉及表型可塑性。表型可塑性允许基因型在非遗传扰动（包括基因表达噪音、环境变化或表观遗传修饰）后产生不同的替代表型。我们在这里分析了一个经过充分研究的基因调控回路模型。电路的基因型编码电路基因之间的调节相互作用，其表型对应于电路形成的稳定的基因活动模式。对于这个模型，我们研究基因型在基因型空间中的排列方式，其中两个基因型之间的距离反映了将这些基因型分开的调节突变的数量。具体来说，我们讨论这种安排是否有利于可塑性介导的适应性进化。我们发现可塑性促进了基因型的起源，从而产生新的表型以响应非遗传扰动。我们还发现，选择可以在遗传上稳定新的表型，使其成为回路的显性基因表达表型。这些是我们在这里研究的电路的通用属性。综上所述，我们的观察表明，表型可塑性经常促进基因调控回路中新型有益基因活动模式的进化。
Many important evolutionary adaptations originate in the modification of gene regulatory circuits to produce new gene activity phenotypes. How do evolving populations sift through an astronomical number of circuits to find circuits with new adaptive phenotypes? The answer may often involve phenotypic plasticity. Phenotypic plasticity allows a genotype to produce different - alternative - phenotypes after non-genetic perturbations that include gene expression noise, environmental change, or epigenetic modification. We here analyze a well-studied model of gene regulatory circuits. A circuit's genotype encodes the regulatory interactions among circuit genes, and its phenotype corresponds to a stable gene activity pattern the circuit forms. For this model, we study how genotypes are arranged in genotype space, where the distance between two genotypes reflects the number of regulatory mutations that set those genotypes apart. Specifically, we address whether this arrangement favors adaptive evolution mediated by plasticity. We find that plasticity facilitates the origin of genotypes that produce a new phenotype in response to non-genetic perturbations. We also find that selection can then stabilize the new phenotype genetically, allowing it to become a circuit's dominant gene expression phenotype. These are generic properties of the circuits we study here. Taken together, our observations suggest that phenotypic plasticity frequently facilitates the evolution of novel beneficial gene activity patterns in gene regulatory circuits.
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影响因子：
4.3
作者：
Espinosa-Soto C;Wagner A
通讯作者：
Wagner A
影响因子：
4
作者：
Braendle, Christian;Flatt, Thomas
通讯作者：
Flatt, Thomas
DOI：
10.1073/pnas.0801201105
发表时间：
2008-04-22
影响因子：
11.1
作者：
Gao, Feng;Davidson, Eric H.
通讯作者：
Davidson, Eric H.
影响因子：
3.7
作者：
Carey, Charles C.;Gorman, Kristen F.;Rutherford, Suzannah
通讯作者：
Rutherford, Suzannah
DOI：
10.1073/pnas.0806007105
发表时间：
2008-12-23
影响因子：
11.1
作者：
Davidson, Eric H.;Levine, Michael S.
通讯作者：
Levine, Michael S.