Characterisation of the UK high energy proton research beamline for high and ultra-high dose rate (FLASH) irradiation
Characterisation of the UK high energy proton research beamline for high and ultra-high dose rate (FLASH) irradiation
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英国高能质子研究光束线高剂量率和超高剂量率 (FLASH) 辐照的表征
DOI：
10.1088/2057-1976/acef25
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发表时间：
2023
影响因子：
1.4
通讯作者：
Aylward J
中科院分区：
文献类型：
--
作者：
Aylward J
目的介绍克里斯蒂质子治疗中心研制的高能质子研究束线用于超高剂量率（UHDR）照射和FLASH实验的能力。它还描述了这种铅笔束扫描（PBS）质子硬件的UHDR操作下限。方法利用法拉第杯光束集热器测量与能量相关的喷嘴透射率。利用二维闪烁探测器在参考平面上测量光斑大小。测量综合深度剂量（IDDs）。采用EBT3荧光膜对UHDR和常规剂量率点进行比较。描述了我们的超高dr光束监测器校准方法。微金刚石探测器用于确定z ref处的剂量率。计算了70 - 245mev的瞬时深度剂量率。PBS剂量率分布采用Folkerts和Van der Water定义计算。主要结果在峰值瞬时剂量率为112.7 Gy s−1时，透射率为7.05±0.1%。光斑尺寸σ x= 4.6 mm, σ y= 6.6 mm，在常规模式和UHDR模式下光束参数可比较。在当前配置中，波束监测电子器件中的死区时间保证了与波束电流相关的MU校正。26.4 ms−1 (X)和12.1 ms−1 (Y)的快速光束扫描允许PBS剂量率为每秒几十格雷斯。在我们的设施中，euhdr传输可以用于小场尺寸和高能量，从而可以用PBS质子研究FLASH效应。据我们所知，这也是第一次使用该临床加速器的硬件在能量低于250兆电子伏的情况下对UHDR辐射进行彻底的表征。本出版物中列出的数据可用于该英国研究机构的实验设计，并为UHDR PBS质子治疗可能的未来临床转化提供信息。
ObjectiveThis work sets out the capabilities of the high energy proton research beamline developed in the Christie proton therapy centre for Ultra-High Dose Rate (UHDR) irradiation and FLASH experiments. It also characterises the lower limits of UHDR operation for this Pencil Beam Scanning (PBS) proton hardware.ApproachEnergy dependent nozzle transmission was measured using a Faraday Cup beam collector. Spot size was measured at the reference plane using a 2D scintillation detector. Integrated depth doses (IDDs) were measured. EBT3 Gafchromic film was used to compare UHDR and conventional dose rate spots. Our beam monitor calibration methodolgy for UHDR is described. A microDiamond detector was used to determine dose rates at z ref. Instantaneous depth dose rates were calculated for 70–245 MeV. PBS dose rate distributions were calculated using Folkerts and Van der Water definitions.Main resultsTransmission of 7.05±0.1% is achieveable corresponding to a peak instantaneous dose rate of 112.7 Gy s− 1. Beam parameters are comparable in conventional and UHDR mode with a spot size of σ x= 4.6 mm, σ y= 6.6 mm. Dead time in the beam monitoring electonics warrants a beam current dependent MU correction in the present configuration. Fast beam scanning of 26.4 ms− 1 (X) and 12.1 ms− 1 (Y) allows PBS dose rates of the order tens of Grays per second.SignificanceUHDR delivery is possible for small field sizes and high energies enabling research into the FLASH effect with PBS protons at our facility. To our knowledge this is also the first thorough characterisation of UHDR irradiation using the hardware of this clinical accelerator at energies less than 250 MeV. The data set out in this publication can be used for designing experiments at this UK research facility and inform the possible future clinical translation of UHDR PBS proton therapy.
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影响因子：
1.7
作者：
Beyreuther, Elke;Baumann, Michael;Luehr, Armin
通讯作者：
Luehr, Armin
影响因子：
3.8
作者：
Folkerts MM;Abel E;Busold S;Perez JR;Krishnamurthi V;Ling CC
通讯作者：
Ling CC
对质子铅笔梁扫描闪光放射疗法的3D剂量率的定量评估及其用于肺部低分治疗计划的应用。
影响因子：
5.2
作者：
Kang M;Wei S;Choi JI;Simone CB 2nd;Lin H
通讯作者：
Lin H
影响因子：
3.4
作者：
Vozenin, M-C;Hendry, J. H.;Limoli, C. L.
通讯作者：
Limoli, C. L.