Sex differences in recovery of motor function in a rhesus monkey model of cortical injury.
Sex differences in recovery of motor function in a rhesus monkey model of cortical injury.
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DOI：
10.1186/s13293-021-00398-9
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发表时间：
2021-10-09
影响因子：
7.9
通讯作者：
Moore TL
中科院分区：
文献类型：
--
作者：
Bottenfield KR;Bowley BGE;Pessina MA;Medalla M;Rosene DL;Moore TL
中风对男性和女性的影响不成比例，65岁以上的女性比男性遭受更严重的损伤和更高的死亡率。人类研究已经探索了导致这些差异的风险因素，但还需要进一步的研究来调查性别差异如何影响功能恢复，从而影响损伤的严重程度。在本研究中，我们使用我们的恒河猴皮质损伤和精细运动损伤模型来比较这种损伤后运动恢复的速度和程度的性别差异。老年雄性和雌性恒河猴在接受手术前进行手部精细运动功能的训练，以产生仅限于手部区域的初级运动皮层的皮层损伤。术后检查在术后两周开始，并持续了12周。所有试验均录像记录，并定量测量获得奖励的潜伏期，以评估与术前相比，术后反应潜伏期和抓取模式的轨迹。死后分析显示，雄性和雌性猴子的病变体积没有差异。然而，雌猴恢复到术前潜伏期和抓握模式的速度明显快于雄猴。这些发现表明，需要进一步研究雌激素和其他性激素的作用，它们可能对灵长类动物大脑的恢复结果产生不同的影响。在接受精细运动任务训练的老年雌性和雄性恒河猴手术前，对代表初级运动皮层的手部区域进行损伤。在皮层损伤后，老年雌性猴子比老年雄性猴子更快地恢复到术前潜伏期和抓取模式
Stroke disproportionately affects men and women, with women over 65 years experiencing increased severity of impairment and higher mortality rates than men. Human studies have explored risk factors that contribute to these differences, but additional research is needed to investigate how sex differences affect functional recovery and hence the severity of impairment. In the present study, we used our rhesus monkey model of cortical injury and fine motor impairment to compare sex differences in the rate and degree of motor recovery following this injury. Aged male and female rhesus monkeys were trained on a task of fine motor function of the hand before undergoing surgery to produce a cortical lesion limited to the hand area representation of the primary motor cortex. Post-operative testing began two weeks after the surgery and continued for 12 weeks. All trials were video recorded and latency to retrieve a reward was quantitatively measured to assess the trajectory of post-operative response latency and grasp pattern compared to pre-operative levels. Postmortem analysis showed no differences in lesion volume between male and female monkeys. However, female monkeys returned to their pre-operative latency and grasp patterns significantly faster than males. These findings demonstrate the need for additional studies to further investigate the role of estrogens and other sex hormones that may differentially affect recovery outcomes in the primate brain. Aged female and male rhesus monkeys were trained on a fine motor task before undergoing surgery to produce a lesion to the hand area representation of the primary motor cortex Aged female monkeys returned to pre-operative latency and grasp patterns faster than aged males after cortical injury
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影响因子：
16.2
作者：
Corbetta M;Ramsey L;Callejas A;Baldassarre A;Hacker CD;Siegel JS;Astafiev SV;Rengachary J;Zinn K;Lang CE;Connor LT;Fucetola R;Strube M;Carter AR;Shulman GL
通讯作者：
Shulman GL
影响因子：
15.1
作者：
Espinosa-Garcia, Claudia;Sayeed, Iqbal;Stein, Donald G.
通讯作者：
Stein, Donald G.
DOI：
10.1016/j.jstrokecerebrovasdis.2005.06.002
发表时间：
2005-09-01
期刊：
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
影响因子：
--
作者：
Andersen, Morten Nonboe;Andersen, Klaus Kaae;Olsen, Tom Skyhoj
通讯作者：
Olsen, Tom Skyhoj
影响因子：
8.3
作者：
Di Carlo, A;Lamassa, M;Inzitari, D
通讯作者：
Inzitari, D
影响因子：
8.3
作者：
FLAMM, ES;DEMOPOULOS, HB;RANSOHOFF, J
通讯作者：
RANSOHOFF, J