Broad inhibition sharpens orientation selectivity by expanding input dynamic range in mouse simple cells.
Broad inhibition sharpens orientation selectivity by expanding input dynamic range in mouse simple cells.
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DOI：
10.1016/j.neuron.2011.06.017
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发表时间：
2011-08-11
期刊：
影响因子：
16.2
通讯作者：
Tao HW
中科院分区：
文献类型：
--
作者：
Liu BH;Li YT;Ma WP;Pan CJ;Zhang LI;Tao HW
方向选择性（OS）是初级视皮层（V1）的一种新特性。OS是如何从突触回路中产生的仍然没有解决。在这里，小鼠V1的体内全细胞记录显示，简单的细胞接受了广泛的调节兴奋和更广泛的调节抑制。兴奋和抑制具有相似的方向偏好，并且在时间上基本重叠。神经元建模和动态钳记录进一步揭示，兴奋性输入单独会导致膜电位反应与显着衰减的选择性，由于饱和的输入输出功能的膜过滤。抑制改善了兴奋性选择性的衰减，通过扩大输入的动态范围，并导致额外的锐化输出响应超出非选择性抑制反应在所有方向。这种“模糊锐化”效应允许兴奋性输入传达的选择性被更好地表达，这可能是面对弱偏置的强兴奋性输入时产生特征选择性反应的一般机制。
Orientation selectivity (OS) is an emergent property in the primary visual cortex (V1). How OS arises from synaptic circuits remains unsolved. Here, in vivo whole-cell recordings in the mouse V1 revealed that simple cells received broadly tuned excitation and even more broadly tuned inhibition. Excitation and inhibition shared a similar orientation preference and temporally overlapped substantially. Neuron modeling and dynamic-clamp recording further revealed that excitatory inputs alone would result in membrane potential responses with significantly attenuated selectivity, due to a saturating input-output function of the membrane filtering. Inhibition ameliorated the attenuation of excitatory selectivity by expanding the input dynamic range, and caused additional sharpening of output responses beyond unselectively suppressing responses at all orientations. This “blur-sharpening” effect allows selectivity conveyed by excitatory inputs to be better expressed, which may be a general mechanism underlying the generation of feature-selective responses in the face of strong excitatory inputs that are weakly biased.
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影响因子：
25
作者：
Dantzker, JL;Callaway, EM
通讯作者：
Callaway, EM
影响因子：
2.5
作者：
MANGINI, NJ;PEARLMAN, AL
通讯作者：
PEARLMAN, AL
影响因子：
25
作者：
Mariño, J;Schummers, J;Sur, M
通讯作者：
Sur, M
影响因子：
2.5
作者：
Miller, KD;Troyer, TW
通讯作者：
Troyer, TW
DOI：
10.1523/jneurosci.5753-10.2011
发表时间：
2011-04-20
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Katzner S;Busse L;Carandini M
通讯作者：
Carandini M