Umbilical cord mercury concentration as biomarker of prenatal exposure to methylmercury.
Umbilical cord mercury concentration as biomarker of prenatal exposure to methylmercury.
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DOI：
10.1289/ehp.7842
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发表时间：
2005-07
影响因子：
10.4
通讯作者：
Weihe P
中科院分区：
文献类型：
--
作者：
Grandjean P;Budtz-Jørgensen E;Jørgensen PJ;Weihe P
在研究和监测中，生物标志物通常用于评估产前甲基汞暴露情况。在法罗群岛的一项前瞻性研究中，主要的暴露生物标志物是分娩时获得的脐带血和母亲头发中的汞浓度。现在，我们通过对 447 名新生儿的脐带组织进行汞分析来补充这些暴露生物标志物。特别是，当以组织干重表示时，脐带汞浓度与脐带血中的汞浓度密切相关。结构方程模型分析表明，这两个生物标志物的平均总不精确度约为30%，远高于实验室误差。基于干重的浓度的不精确度低于基于湿重的参数的不精确度，并且介于脐带血和头发生物标志物的不精确度之间。与这一发现一致的是，回归分析表明，干重脐带汞浓度几乎与脐带血汞浓度一样，可以很好地预测 7 岁时甲基汞相关的神经心理缺陷。因此，脐带汞分析可用作产前甲基汞暴露的有效测量，但应考虑对不精确性进行适当调整。
Biomarkers are often applied to assess prenatal exposure to methylmercury in research and surveillance. In a prospective study in the Faroe Islands, the main exposure biomarkers were the mercury concentrations in cord blood and maternal hair obtained at parturition. We have now supplemented these exposure biomarkers with mercury analyses of umbilical cord tissue from 447 births. In particular, when expressed in relation to the dry weight of the tissue, the cord mercury concentration correlated very well with that in cord blood. Structural equation model analysis showed that these two biomarkers have average total imprecision of about 30%, which is much higher than the laboratory error. The imprecision of the dry-weight–based concentration was lower than that of the wet-weight–based parameter, and it was intermediate between those of the cord blood and the hair biomarkers. In agreement with this finding, regression analyses showed that the dry-weight cord mercury concentration was almost as good a predictor of methylmercury-associated neuropsychologic deficits at 7 years of age as was the cord-blood mercury concentration. Cord mercury analysis can therefore be used as a valid measure of prenatal methylmercury exposure, but appropriate adjustment for the imprecision should be considered.
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影响因子：
10.4
作者：
Dalgard C;Grandjean P;Jorgensen PJ;Weihe P
通讯作者：
Weihe P
影响因子：
8.3
作者：
Huang, LS;Cox, C;Clarkson, TW
通讯作者：
Clarkson, TW
影响因子：
3.4
作者：
SCOTT, JM;WILKINSON, R
通讯作者：
WILKINSON, R
影响因子：
2
作者：
Budtz-Jorgensen, E;Keiding, N;White, RF
通讯作者：
White, RF
DOI：
10.1177/096032718400300205
发表时间：
1984-01-01
期刊：
HUMAN TOXICOLOGY
影响因子：
--
作者：
SHERLOCK, J;HISLOP, J;WHITTLE, K
通讯作者：
WHITTLE, K