Reciprocal interactions between transforming growth factor beta signaling and collagens: Insights from Caenorhabditis elegans.

Reciprocal interactions between transforming growth factor beta signaling and collagens: Insights from Caenorhabditis elegans.
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DOI:
10.1002/dvdy.423
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发表时间:
2022-01
期刊:
Developmental dynamics : an official publication of the American Association of Anatomists
影响因子:
--
通讯作者:
Savage-Dunn C
Savage-Dunn C
中科院分区:
其他
文献类型:
--
作者:
Goodman MB;Savage-Dunn C

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Studies in genetically tractable organisms such as the nematode Caenorhabditis elegans have led to pioneering insights into conserved developmental regulatory mechanisms. For example, Smad signal transducers for the TGF-β superfamily were first identified in C. elegans and in the fruit fly Drosophila. Recent studies of TGF-β signaling and the extracellular matrix (ECM) in C. elegans have forged unexpected links between signaling and the ECM, yielding novel insights into the reciprocal interactions that occur across tissues and spatial scales, and potentially providing new opportunities for the study of biomechanical regulation of gene expression.
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