Ripple-selective GABAergic projection cells in the hippocampus.
Ripple-selective GABAergic projection cells in the hippocampus.
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DOI：
10.1016/j.neuron.2022.04.002
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发表时间：
2022-06-15
期刊：
影响因子：
16.2
通讯作者：
Soltesz, Ivan
中科院分区：
文献类型：
--
作者：
Szabo, Gergely G.;Farrell, Jordan S.;Dudok, Barna;Hou, Wen-Hsien;Ortiz, Anna L.;Varga, Csaba;Moolchand, Prannath;Gulsever, Cafer Ikbal;Gschwind, Tilo;Dimidschstein, Jordane;Capogna, Marco;Soltesz, Ivan
波纹是短暂的高频电描记事件，在情景记忆中发挥重要作用。然而，协调局部和远端神经元群之间的纹波相关活动的体内电路机制尚不清楚。在这里，我们定义了小鼠海马体中长距离投射 GABA 能细胞群的关键特征，该细胞群在波动期间选择性地表现出高频放电，而在大多数其他 GABA 能细胞活跃时在 θ 相关状态下保持基本沉默。与高纹波相关的发射在纹波出现之前开始，并在纹波峰值之前达到最大值，并且在清醒和睡眠状态下保留了标志性的 theta-off、纹波开启发射模式。这些波纹选择性细胞受间隔 GABA 能、胆碱能和 CA3 谷氨酸输入控制，支配小清蛋白和表达胆囊收缩素的局部中间神经元，同时还针对各种海马外区域。这些结果证明了海马 GABA 能回路元件的存在，该元件具有独特的定位来协调跨神经元组件的纹波相关神经元动力学。萨博等人。鉴定出具有远距离投射和独特活动动态的海马 GABA 能细胞子集。 Theta-OFF/Ripple-ON (TORO) 细胞在运动和快速眼动睡眠 theta 期间几乎保持沉默，但在尖锐的波波纹期间剧烈放电。 TORO 细胞接收 CA3 谷氨酸能、间隔 GABA 能和抑制性胆碱能输入并靶向中间神经元。
Ripples are brief high-frequency electrographic events with important roles in episodic memory. However, the in vivo circuit mechanisms coordinating ripple-related activity among local and distant neuronal ensembles are not well understood. Here we define key characteristics of a long-distance projecting GABAergic cell group in the mouse hippocampus that selectively exhibits high-frequency firing during ripples while staying largely silent during theta-associated states when most other GABAergic cells are active. The high ripple-associated firing commenced before ripple onset and reached its maximum before ripple peak, with the signature theta-off, ripple-on firing pattern being preserved across awake and sleep states. Controlled by septal GABAergic, cholinergic, and CA3 glutamatergic inputs, these ripple-selective cells innervate parvalbumin and cholecystokinin-expressing local interneurons while also targeting a variety of extra-hippocampal regions. These results demonstrate the existence of a hippocampal GABAergic circuit element that is uniquely positioned to coordinate ripple-related neuronal dynamics across neuronal assemblies. Szabo et al. identify a subset of hippocampal GABAergic cells with long-range projections and unique activity dynamics. Theta-OFF/Ripple-ON (TORO) cells are virtually silent during locomotion- and REM sleep theta but fire vigorously during sharp wave-ripples. TORO cells receive CA3 glutamatergic, septal GABAergic and inhibitory cholinergic inputs and target interneurons.
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