Distribution Heterogeneity of Muscle Spindles Across Skeletal Muscles of Lower Extremities in C57BL/6 Mice.
Distribution Heterogeneity of Muscle Spindles Across Skeletal Muscles of Lower Extremities in C57BL/6 Mice.
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C57BL/6 小鼠下肢骨骼肌肌梭分布异质性
DOI：
10.3389/fnana.2022.838951
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发表时间：
2022
影响因子：
2.9
通讯作者：
Li X
中科院分区：
文献类型：
--
作者：
Lian W;Hao F;Hao P;Zhao W;Gao Y;Rao JS;Duan H;Yang Z;Li X
肌纺锤体是分散在骨骼肌中的一种重要本体感受器，参与维持肌肉张力和对随机运动的精细调节。虽然肌纺锤体存在于所有骨骼肌中，但对肌纺锤体分布和形态的解释仍然缺乏，无法确定肌纺锤体在肌肉中的位置。本研究采用传统耗时的组织化学技术测定C57BL/6小鼠下肢骨骼肌肌梭解剖形态学特征。在腹背方向的肌肉中，纺锤体到神经入口点的相对距离不同，其中腓肠肌外侧的纺锤体不被认为靠近神经入口点。在纵向模式中，纺锤体丰度最高的区域对应于神经入口点，不包括胫骨前肌。纺锤体主要集中在所有肌肉的中部和吻侧区域。结果表明，纺锤体在不同肌肉中的分布存在异质性，但其分布趋势一般遵循神经入口点的位置模式。组织化学染色显示纺锤体不具有沿赤道的对称结构，这一结果与先前的发现不一致。探索骨骼肌肌梭的分布和结构特征，可以为分子水平上肌梭的研究和运动相关疾病的治疗提供一定的解剖学基础，并提供对肌梭形态的全面认识。
Muscle spindles, an important proprioceptor scattered in the skeletal muscle, participate in maintaining muscle tension and the fine regulation of random movement. Although muscle spindles exist in all skeletal muscles, explanations about the distribution and morphology of muscle spindles remain lacking for the indetermination of spindle location across muscles. In this study, traditional time-consuming histochemical technology was utilized to determine the muscle spindle anatomical and morphological characteristics in the lower extremity skeletal muscle in C57BL/6 mice. The relative distance from spindles to nerve-entry points varied from muscles in the ventral-dorsal direction, in which spindles in the lateral of gastrocnemius were not considered to be close to its nerve-entry point. In the longitudinal pattern, the domain with the highest abundance of spindles corresponded to the nerve-entry point, excluding the tibialis anterior. Spindles are mainly concentrated at the middle and rostral domain in all muscles. The results suggest a heterogeneity of the distribution of spindles in different muscles, but the distribution trend generally follows the location pattern of the nerve-entry point. Histochemical staining revealed that the spindle did not have a symmetrical structure along the equator, and this result does not agree with previous findings. Exploring the distribution and structural characteristics of muscle spindles in skeletal muscle can provide some anatomical basis for the study of muscle spindles at the molecular level and treatment of exercise-related diseases and provide a comprehensive understanding of muscle spindle morphology.
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影响因子：
7.7
作者：
Muller, Karra A.;Ryals, Janelle M.;Wright, Douglas E.
通讯作者：
Wright, Douglas E.
影响因子：
4.7
作者：
Macefield, Vaughan G.
通讯作者：
Macefield, Vaughan G.
影响因子：
5.3
作者：
Fernandes, Michelle Oliveira;Tourtellotte, Warren G.
通讯作者：
Tourtellotte, Warren G.
将神经营养蛋白3转染到神经干细胞中，并使用微泡超声处理，以治疗已取消的肌肉萎缩。
影响因子：
2.7
作者：
Gong L;Jiang C;Liu L;Wan S;Tan W;Ma S;Jia X;Wang M;Hu A;Shi Y;Zhang Y;Shen Y;Wang F;Chen Y
通讯作者：
Chen Y
DOI：
10.1109/tbme.2008.2008193
发表时间：
2009-02
期刊：
IEEE transactions on bio-medical engineering
影响因子：
--
作者：
Kim SJ;Fairchild MD;Iarkov Yarkov A;Abbas JJ;Jung R
通讯作者：
Jung R