Cell size control in yeast.

Cell size control in yeast.
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DOI:
10.1016/j.cub.2012.02.041
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发表时间:
2012-05-08
期刊:
影响因子:
9.2
通讯作者:
Skotheim, Jan M.
Skotheim, Jan M.
中科院分区:
生物学1区
文献类型:
--
作者:
Turner, Jonathan J.;Ewald, Jennifer C.;Skotheim, Jan M.

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细胞大小是一个重要的适应性特征,几乎影响到细胞生理学的各个方面。尽管细胞周期调控网络具有广泛的特征,但从生长到分裂,从而控制细胞大小的分子机制仍然难以捉摸。最近在酵母中的研究重新活跃了大小控制领域,并提出了刺激机制,以实现设定和感知细胞大小的不同功能。进一步研究基于空间梯度和分子滴定的大小感知模型,再加上阐明营养调控靶大小的途径,可能会揭示真核细胞大小控制的基本原理。
Cell size is an important adaptive trait that influences nearly all aspects of cellular physiology. Despite extensive characterization of the cell cycle regulatory network, the molecular mechanismscoupling growth to division, and thereby controlling cell size, have remained elusive. Recent workin yeast has reinvigorated the size control field and suggested provocative mechanisms forthe distinct functions of setting and sensing cell size. Further examination of size sensing models based on spatial gradients and molecular titration, coupled with elucidation of the pathways responsible for nutrient-modulated target size, may reveal the fundamental principles of eukaryotic cell size control.
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