Cell size control in yeast.
Cell size control in yeast.
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DOI:
10.1016/j.cub.2012.02.041
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发表时间:
2012-05-08
期刊:
影响因子:
9.2
通讯作者:
Skotheim, Jan M.
中科院分区:
文献类型:
--
作者:
Turner, Jonathan J.;Ewald, Jennifer C.;Skotheim, Jan M.
Cell size is an important adaptive trait that influences nearly all aspects of cellular physiology. Despite extensive characterization of the cell cycle regulatory network, the molecular mechanismscoupling growth to division, and thereby controlling cell size, have remained elusive. Recent workin yeast has reinvigorated the size control field and suggested provocative mechanisms forthe distinct functions of setting and sensing cell size. Further examination of size sensing models based on spatial gradients and molecular titration, coupled with elucidation of the pathways responsible for nutrient-modulated target size, may reveal the fundamental principles of eukaryotic cell size control.
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