CD4 T-cell subsets in malaria: TH1/TH2 revisited.
CD4 T-cell subsets in malaria: TH1/TH2 revisited.
复制标题
DOI：
10.3389/fimmu.2014.00671
复制
发表时间：
2014
影响因子：
7.3
通讯作者：
Langhorne J
中科院分区：
文献类型：
--
作者：
Perez-Mazliah D;Langhorne J
CD4+ t细胞已被证明在疟原虫感染的免疫控制中发挥核心作用。在感染的红细胞阶段，CD4+ t细胞和帮助b细胞应答的CD4+ t细胞产生IFN-γ是控制和消除感染红细胞所必需的。CD4+ t细胞通过激活寄生虫特异性CD8+ t细胞对控制疟原虫红细胞前阶段也很重要。然而，过度的炎症反应引发的感染已被证明驱动病理。早期的经典实验证明了小鼠红细胞阶段的双相CD4+ T细胞反应，其中辅助性T细胞（Th）1和抗体辅助性CD4+ T细胞在原发性感染期间依次出现。虽然产生IFN-γ的Th1细胞确实在控制急性感染中发挥作用，并且它们有助于急性红细胞期病理，但很明显，在感染的慢性期，产生IL-4的经典Th2反应并不是CD4+ t细胞反应的关键特征。相反，在缺乏IL-4的情况下，有效的CD4+ t细胞对b细胞的帮助是控制慢性寄生虫病所必需的。在人类和实验模型中，IL-10对平衡炎症很重要，并与预防炎症介导的严重疟疾有关，最初被认为是在感染期间由CD4+ Th2细胞产生的。我们回顾了疟原虫感染期间CD4+ T细胞反应的解释，根据最近的进展，包括鉴定多功能T细胞，如Th1细胞共表达IFN-γ和IL-10，鉴定滤泡辅助性T细胞（Tfh）作为b细胞的主要CD4+ T辅助性亚群，以及识别不同CD4+ T细胞命运的固有可塑性。
CD4+ T-cells have been shown to play a central role in immune control of infection with Plasmodium parasites. At the erythrocytic stage of infection, IFN-γ production by CD4+ T-cells and CD4+ T-cell help for the B-cell response are required for control and elimination of infected red blood cells. CD4+ T-cells are also important for controlling Plasmodium pre-erythrocytic stages through the activation of parasite-specific CD8+ T-cells. However, excessive inflammatory responses triggered by the infection have been shown to drive pathology. Early classical experiments demonstrated a biphasic CD4+ T-cell response against erythrocytic stages in mice, in which T helper (Th)1 and antibody-helper CD4+ T-cells appear sequentially during a primary infection. While IFN-γ-producing Th1 cells do play a role in controlling acute infections, and they contribute to acute erythrocytic-stage pathology, it became apparent that a classical Th2 response producing IL-4 is not a critical feature of the CD4+ T-cell response during the chronic phase of infection. Rather, effective CD4+ T-cell help for B-cells, which can occur in the absence of IL-4, is required to control chronic parasitemia. IL-10, important to counterbalance inflammation and associated with protection from inflammatory-mediated severe malaria in both humans and experimental models, was originally considered be produced by CD4+ Th2 cells during infection. We review the interpretations of CD4+ T-cell responses during Plasmodium infection, proposed under the original Th1/Th2 paradigm, in light of more recent advances, including the identification of multifunctional T-cells such as Th1 cells co-expressing IFN-γ and IL-10, the identification of follicular helper T-cells (Tfh) as the predominant CD4+ T helper subset for B-cells, and the recognition of inherent plasticity in the fates of different CD4+ T-cells.
登录
查看更多内容
影响因子：
30.5
作者：
Butler, Noah S.;Moebius, Jacqueline;Pewe, Lecia L.;Traore, Boubacar;Doumbo, Ogobara K.;Tygrett, Lorraine T.;Waldschmidt, Thomas J.;Crompton, Peter D.;Harty, John T.
通讯作者：
Harty, John T.
影响因子：
82.9
作者：
通讯作者：
--
CD8- DC 中的 I 型 IFN 信号会损害 Th1 依赖性疟疾免疫力
影响因子：
15.9
作者：
Haque, Ashraful;Best, Shannon E.;Engwerda, Christian R.
通讯作者：
Engwerda, Christian R.
影响因子：
30.5
作者：
Duhen, Thomas;Geiger, Rebekka;Sallusto, Federica
通讯作者：
Sallusto, Federica
影响因子：
4.4
作者：
da Silva, Henrique Borges;de Salles, Erika Machado;D'Imperio Lima, Maria Regina
通讯作者：
D'Imperio Lima, Maria Regina