Cytotoxic and antibacterial angucycline- and prodigiosin-analogues from the deep-sea derived Streptomyces sp. SCSIO 11594.
Cytotoxic and antibacterial angucycline- and prodigiosin-analogues from the deep-sea derived Streptomyces sp. SCSIO 11594.
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DOI：
10.3390/md13031304
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发表时间：
2015-03-16
期刊：
影响因子：
5.4
通讯作者：
Ju J
中科院分区：
文献类型：
--
作者：
Song Y;Liu G;Li J;Huang H;Zhang X;Zhang H;Ju J
两种新的C-糖苷angucycline，marangucycline A（1）和marangucycline B（2），沿着三种已知化合物，dehydroxyaquayamycin（3），十一烷基灵菌红素（4）和metacycloprodigiosin（5），已被确定为深海沉积物链霉菌SCSIO 11594菌株的产物。新的结构被阐明的基础上HRESIMS，1D和2D NMR分析和比较，以前报道的数据集。化合物2和4对四种癌细胞系A594、CNE 2、HepG 2、MCF-7的体外细胞毒性上级用顺铂（阳性对照）获得的那些。值得注意的是，带有酮-糖的化合物2对癌细胞系显示出显著的细胞毒性，IC 50值范围为0.24至0.56 μM;当使用非癌肝细胞系HL 7702时，发现IC 50值为3.67 μM，证明了2的癌细胞选择性。化合物1-3对粪肠球菌ATCC 29212有较弱的抗菌活性，MIC值为64.0 μg/mL。3对耐甲氧西林表皮葡萄球菌shhs-E1具有选择性抗菌活性，MIC值为16.0 μg/mL。
Two new C-glycoside angucyclines, marangucycline A (1) and marangucycline B (2), along with three known compounds, dehydroxyaquayamycin (3), undecylprodigiosin (4) and metacycloprodigiosin (5), have been identified as products of the deep-sea sediment strain Streptomyces sp. SCSIO 11594. New structures were elucidated on the basis of HRESIMS, 1D and 2D NMR analyses and comparisons to previously reported datasets. Compounds 2 and 4 displayed in vitro cytotoxicity against four cancer cell lines A594, CNE2, HepG2, MCF-7 superior to those obtained with cisplatin, the positive control. Notably, compound 2 bearing a keto-sugar displayed significant cytotoxicity against cancer cell lines with IC50 values ranging from 0.24 to 0.56 μM; An IC50 value of 3.67 μM was found when using non-cancerous hepatic cell line HL7702, demonstrating the cancer cell selectivity of 2. Compounds 1–3 were proved to have weak antibacterial activities against Enterococcus faecalis ATCC29212 with an MIC value of 64.0 μg/mL. Moreover, 3 displayed selective antibacterial activity against methicillin-resistant Staphylococcus epidermidis shhs-E1 with an MIC value of 16.0 μg/mL.
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影响因子：
5
作者：
Cheung RC;Wong JH;Pan WL;Chan YS;Yin CM;Dan XL;Wang HX;Fang EF;Lam SK;Ngai PH;Xia LX;Liu F;Ye XY;Zhang GQ;Liu QH;Sha O;Lin P;Ki C;Bekhit AA;Bekhit Ael-D;Wan DC;Ye XJ;Xia J;Ng TB
通讯作者：
Ng TB
Marthiapeptide A 是一种抗感染和细胞毒性聚噻唑环肽，来自深海来源的耐热滨海藻 SCSIO 00652 的 60 L 规模发酵。
影响因子：
5.1
作者：
Zhou, Xiao;Huang, Hongbo;Ju, Jianhua
通讯作者：
Ju, Jianhua
影响因子：
5.2
作者：
Yu, Xiaomei;O'Doherty, George A.
通讯作者：
O'Doherty, George A.
影响因子：
1.7
作者：
Supong, Khomsan;Thawai, Chitti;Pittayakhajonwut, Pattama
通讯作者：
Pittayakhajonwut, Pattama
影响因子：
5.1
作者：
Abdelfattah, Mohamed S.;Kharel, Madan Kumar;Hitron, John Andrew;Baig, Irfan;Rohr, Juergen
通讯作者：
Rohr, Juergen