Clinical features of bipolar disorder comorbid with anxiety disorders differ between men and women.
Clinical features of bipolar disorder comorbid with anxiety disorders differ between men and women.
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男性和女性的躁郁症合并症与焦虑症的临床特征不同。
DOI：
10.1002/da.21932
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发表时间：
2012-08
影响因子：
7.4
通讯作者：
McInnis, Melvin G.
中科院分区：
文献类型：
--
作者：
Saunders, Erika F. H.;Fitzgerald, Kate D.;Zhang, Peng;McInnis, Melvin G.
焦虑症通常与双相情感障碍（BP）共病，并可能使病程恶化，但具体的焦虑症在男性和女性中的差异影响仍然未知。我们测量了共病的惊恐障碍（PD），社交恐惧症，特定恐惧症和强迫症（OCD）的影响，在460名女性和276名男性双相I型障碍（BPI）或情感障碍，双相型从国家精神卫生研究所双相遗传学倡议。我们比较了有和没有每种焦虑症的男性和女性BP的临床特征，分别校正了家庭相关性。共病PD、强迫症和特定恐惧症在女性BP患者中比男性更常见。共病社交恐惧症与BP女性酗酒风险增加相关，但与男性无关。患有PD的女性上学的时间更少。对于两种性别，强迫症的合并症与BP发病的早期年龄相关。与没有这些焦虑障碍的BP患者相比，在两种性别中，共病PD、OCD和特定恐惧症与BP中更多的抗抑郁药试验相关。在BP中，共病焦虑障碍与功能障碍的风险增加相关，女性与男性的相关风险不同。临床医生应该意识到患有BP的女性患PD、OCD和特定恐惧症的风险增加，患有BD和社交恐惧症的女性酗酒的风险增加。
Anxiety disorders are commonly comorbid with bipolar disorder (BP) and may worsen course of illness, but differential impact of specific anxiety disorders in men and women remains unknown. We measured the impact of comorbid panic disorder (PD), social phobia, specific phobia, and obsessive-compulsive disorder (OCD) in 460 women and 276 men with Bipolar I Disorder (BPI) or schizoaffective disorder, bipolar type from the National Institute of Mental Health Bipolar Genetics Initiative. We compared clinical characteristics in BP with and without each anxiety disorder in men and women separately correcting for family relatedness. Comorbid PD, OCD, and specific phobia were more common in women with BP than men. Comorbid social phobia correlated with increased risk of alcohol abuse in BP women, but not men. Women with comorbid PD attended fewer years of school. Comorbidity with OCD was associated with earlier age at the onset of BP for both genders. Comorbid PD, OCD, and specific phobia were associated with more antidepressant trials in BP, across both genders, compared to BP patients without these anxiety disorders. In BP, comorbid anxiety disorders are associated with increased risk for functional impairment, and women had differently associated risks than men. Clinicians should be aware of an increased risk for comorbid PD, OCD, and specific phobia in women with BP, and an increased risk of alcohol abuse in women with BD and comorbid social phobia.
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影响因子：
4.8
作者：
McLean CP;Asnaani A;Litz BT;Hofmann SG
通讯作者：
Hofmann SG
影响因子：
17.7
作者：
Frye, MA;Altshuler, LL;Post, RM
通讯作者：
Post, RM
影响因子：
17.7
作者：
Altshuler, Lori L.;Kupka, Ralph W.;Zermeno, Melanie
通讯作者：
Zermeno, Melanie
影响因子：
3.6
作者：
Ferdinand, Robert F.;Dieleman, Gwen;Ormel, Johan;Verhulst, Frank C.
通讯作者：
Verhulst, Frank C.
影响因子：
--
作者：
Merikangas, Kathleen R.;Akiskal, Hagop S.;Kessler, Ronald C.
通讯作者：
Kessler, Ronald C.