Incidence, mortality, and economic burden of myasthenia gravis in China: A nationwide population-based study.
Incidence, mortality, and economic burden of myasthenia gravis in China: A nationwide population-based study.
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中国重症肌无力的发病率、死亡率和经济负担：一项全国性的人群研究
DOI：
10.1016/j.lanwpc.2020.100063
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发表时间：
2020-12
期刊：
影响因子：
--
通讯作者：
Shi FD
中科院分区：
文献类型：
--
作者：
Chen J;Tian DC;Zhang C;Li Z;Zhai Y;Xiu Y;Gu H;Li H;Wang Y;Shi FD
重症肌无力(MG)是最常见的神经肌肉传递疾病，但MG在中国患者中的发病率尚不清楚。我们在中国进行了第一次全国性研究，确定了全国所有年龄段MG的发病率和死亡率。这项以人口为基础的全国登记研究基于国家卫生健康委员会医院质量监测系统数据库，该数据库覆盖了中国全国31个省市提供重症肌无力护理的1,665家医院。自2016年1月1日至2018年12月31日，共确认59,243名重症肌无力患者94,638人入院。重症肌无力采用ICD-10编码(G70)。重症肌无力的发病率按年龄、性别和省份分层。在59,243名患者中，新诊断出30,503名重症肌无力患者。调整年龄和性别的重症肌无力发病率为0.68/10万人年，70~74岁年龄组发病率最高。女性发病率为0.76/10万，男性为0.60/10万。住院死亡率为14.69‰。呼吸衰竭是肌无力危象患者的主要死亡原因。有14,840名胸腺瘤患者，包括14,636名(26.5%)成年人和204名(7.1%)青少年。胸腺瘤切除9453例(63.7%)。住院时间的中位数为8天(四分位数区间为4至15天)，住院费用中位数为1037美元(四分位数区间为493至2925美元)。基本医疗保险是最常见的支付方式，覆盖了67.4%的患者。中国的年龄和性别调整后的MG发病率为0.68/10万人年。住院死亡率为14.69‰。大多数新发的MG病例发生在生命的第70年。中国国家科学基金(91642205,81830038)；首都医科大学人脑保护高级创新中心，北京
Myasthenia gravis (MG) is the most common primary disorder of neuromuscular transmission, but the incidence of MG in China is unknown. We conducted the first nationwide study to determine the incidence and mortality rates of MG in all age groups at the national level in China. This national population-based registry study is based on the database of the Hospital Quality Monitoring System of National Health Commission, which covers 1665 hospitals providing myasthenia gravis care in 31 provinces and municipalities across China. 94,638 hospital admissions for 59,243 myasthenia gravis patients were identified from January 1st, 2016 to December 31st, 2018. Myasthenia gravis was identified by ICD-10 codes (G70). Incidence of myasthenia gravis was stratified by age, sex, and province. Of 59,243 patients, 30,503 individuals with myasthenia gravis were newly diagnosed. Age and sex adjusted incidence of myasthenia gravis was 0.68 per 100,000 person-years, with highest in the age group of 70–74 years. The incidence in females was 0.76 per 100,000 and 0.60 per 100,000 in males. The admission mortality rate was 14.69‰. Respiratory failure was the leading cause of death in patients with myasthenic crisis. There were 14,840 patients with thymomas, encompassing 14,636 (26.5%) adults and 204 (7.1%) juveniles. 9453 (63.7%) patients with thymomas underwent thymomectomy. The median length of hospital stay was 8 days (interquartile range (IQR) 4 to 15 days) with median hospitalization cost $1037 (IQR $493 to $2925). The Basic Medical Insurance was the most common payment method, covering 67.4% of patients. The age and sex adjusted incidence of MG was 0.68 per 100,000 person-years in China. The admission mortality rate was 14.69‰. Most cases of new onset MG occurred in the seventh decade of life. National Science Foundation of China (91642205, and 81830038); Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing
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影响因子：
9.9
作者：
Neumann, Bernhard;Angstwurm, Klemens;Stetefeld, Henning R.
通讯作者：
Stetefeld, Henning R.
影响因子：
3.4
作者：
Mombaur, Busisiwe;Lesosky, Maia R.;Heckmann, Jeannine M.
通讯作者：
Heckmann, Jeannine M.
影响因子：
29
作者：
Liew, Wendy K. M.;Powell, Christine A.;Kang, Peter B.
通讯作者：
Kang, Peter B.
影响因子：
2.4
作者：
Lee HS;Lee HS;Shin HY;Choi YC;Kim SM
通讯作者：
Kim SM
DOI：
10.1016/s0140-6736(15)00343-8
发表时间：
2015-10-10
期刊：
Lancet (London, England)
影响因子：
--
作者：
Jiang L;Krumholz HM;Li X;Li J;Hu S
通讯作者：
Hu S