MicroRNA-21: An Emerging Player in Bone Diseases.
MicroRNA-21: An Emerging Player in Bone Diseases.
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MicroRNA-21：骨疾病的新兴参与者
DOI：
10.3389/fphar.2021.722804
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发表时间：
2021
影响因子：
5.6
通讯作者：
Wang B
中科院分区：
文献类型：
--
作者：
Chen C;Liu YM;Fu BL;Xu LL;Wang B
MicroRNAs （MiRNAs）是一种小的内源性非编码rna，它结合到靶基因的3 ' -非翻译区，促进其降解或抑制翻译，从而调节基因的表达。mirna在生物学中无处不在，参与许多生物过程，在多种生理病理过程中发挥着重要作用。MiRNA-21 （miR-21）就是其中之一。近年来，miR-21作为骨科疾病中的一个新兴角色受到了研究者的广泛关注。MiR-21通过多种机制与骨科疾病的发生、发展、治疗和预防密切相关。本文就其对成骨细胞、破骨细胞的影响及其与骨质疏松、骨折、骨关节炎（OA）、骨坏死的关系进行综述，为这些骨病的诊断、治疗和预防提供新的思路。
MicroRNAs (MiRNAs) are small endogenous non-coding RNAs that bind to the 3′-untranslated region of target genes and promote their degradation or inhibit translation, thereby regulating gene expression. MiRNAs are ubiquitous in biology and are involved in many biological processes, playing an important role in a variety of physiological and pathological processes. MiRNA-21 (miR-21) is one of them. In recent years, miR-21 has received a lot of attention from researchers as an emerging player in orthopedic diseases. MiR-21 is closely associated with the occurrence, development, treatment, and prevention of orthopedic diseases through a variety of mechanisms. This review summarizes its effects on osteoblasts, osteoclasts and their relationship with osteoporosis, fracture, osteoarthritis (OA), osteonecrosis, providing a new way of thinking for the diagnosis, treatment and prevention of these bone diseases.
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