Marine derived polysaccharides for biomedical applications: chemical modification approaches.
Marine derived polysaccharides for biomedical applications: chemical modification approaches.
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DOI：
10.3390/molecules13092069
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发表时间：
2008-09-03
期刊：
影响因子：
--
通讯作者：
Laurienzo P
中科院分区：
文献类型：
--
作者：
d'Ayala GG;Malinconico M;Laurienzo P
基于多糖的生物材料是几个生物医学领域的新兴材料，如组织再生，特别是软骨，药物输送装置和用于固定细胞的凝胶包埋系统。多糖的重要特性包括可控的生物活性、可生物降解性和形成水凝胶的能力。大多数使用的多糖来自天然来源；特别是海藻酸盐和几丁质，这两种多糖在医学、药学和基础科学中有着广泛的应用历史，分别可以很容易地从海洋植物（海藻）和蟹壳中提取。最近对多糖基材料的重新发现也归因于其化学改性的新合成路线，目的是促进新的生物活性和/或为特定目的修改生物材料的最终性能。这些合成策略还包括多糖与其他聚合物的结合。综述了近年来海藻酸盐、几丁质及其衍生物壳聚糖的化学改性研究进展。此外，我们还报告了我们最近关于各种不同方法和基于多糖的生物材料应用的研究结果，例如基于硫酸钙与海藻酸盐和化学改性壳聚糖混合的新型复合材料的实现，新型海藻酸盐-聚乙二醇共聚物的合成以及基于海藻酸盐和丙烯酸聚合物的一系列材料的开发，这些材料可能作为药物递送系统。
Polysaccharide-based biomaterials are an emerging class in several biomedical fields such as tissue regeneration, particularly for cartilage, drug delivery devices and gel-entrapment systems for the immobilization of cells. Important properties of the polysaccharides include controllable biological activity, biodegradability, and their ability to form hydrogels. Most of the polysaccharides used derive from natural sources; particularly, alginate and chitin, two polysaccharides which have an extensive history of use in medicine, pharmacy and basic sciences, and can be easily extracted from marine plants (algae kelp) and crab shells, respectively. The recent rediscovery of poly-saccharide-based materials is also attributable to new synthetic routes for their chemical modification, with the aim of promoting new biological activities and/or to modify the final properties of the biomaterials for specific purposes. These synthetic strategies also involve the combination of polysaccharides with other polymers. A review of the more recent research in the field of chemical modification of alginate, chitin and its derivative chitosan is presented. Moreover, we report as case studies the results of our recent work concerning various different approaches and applications of polysaccharide-based biomaterials, such as the realization of novel composites based on calcium sulphate blended with alginate and with a chemically modified chitosan, the synthesis of novel alginate-poly(ethylene glycol) copolymers and the development of a family of materials based on alginate and acrylic polymers of potential interest as drug delivery systems.
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影响因子：
5.5
作者：
BELTON, PS;TANNER, SF;CHANZY, H
通讯作者：
CHANZY, H
影响因子：
14
作者：
Balakrishnan, B;Jayakrishnan, A
通讯作者：
Jayakrishnan, A
DOI：
10.1016/s0922-338x(98)80059-7
发表时间：
1998-01-01
期刊：
JOURNAL OF FERMENTATION AND BIOENGINEERING
影响因子：
--
作者：
Chen, JP;Chu, IM;Fu, SH
通讯作者：
Fu, SH
影响因子：
11.2
作者：
Can, Z;Ping, QN;Jian, S
通讯作者：
Jian, S
影响因子：
14
作者：
BIAGINI, G;BERTANI, A;RIZZOLI, C
通讯作者：
RIZZOLI, C