Neuroligin-1-dependent competition regulates cortical synaptogenesis and synapse number.
Neuroligin-1-dependent competition regulates cortical synaptogenesis and synapse number.
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DOI：
10.1038/nn.3256
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发表时间：
2012-12
影响因子：
25
通讯作者：
Sabatini BL
中科院分区：
文献类型：
--
作者：
Kwon HB;Kozorovitskiy Y;Oh WJ;Peixoto RT;Akhtar N;Saulnier JL;Gu C;Sabatini BL
Members of the neuroligin (NL) family of cell-adhesion proteins are found at excitatory and inhibitory synapses and are mutated in some familial forms of autism spectrum disorders. Although they display synaptogenic properties in heterologous systems, a function of NLs in vivo in regulating synapse formation and synapse number has been difficult to establish. Here we show that neuroligin-1 (NL1), which is located at excitatory post-synaptic densities, does regulate activity-dependent synaptogenesis as well as mature synapse number on cortical layer 2/3 pyramidal neurons in vivo. However, synapse number is not sensitive to absolute NL1 levels but rather to transcellular differences in the relative amounts of NL1. These effects are independent of the cell-autonomous regulation of NMDA-type glutamate receptors by absolute levels of NL1. Our data indicate that transcellular competitive processes govern synapse formation and number in developing cortex and that NL1 plays a central function in these processes.
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影响因子：
30.8
作者：
Durand, Christelle M.;Betancur, Catalina;Bourgeron, Thomas
通讯作者：
Bourgeron, Thomas
影响因子：
16.2
作者：
Ko, Jaewon;Fuccillo, Marc V.;Malenka, Robert C.;Suedhof, Thomas C.
通讯作者：
Suedhof, Thomas C.
影响因子：
4.8
作者：
Chubykin, AA;Liu, XR;Südhof, TC
通讯作者：
Südhof, TC
影响因子：
56.9
作者：
Chih, B;Engelman, H;Scheiffele, P
通讯作者：
Scheiffele, P
经验在皮质回路中留下了持久的结构痕迹。
影响因子：
64.8
作者：
Hofer SB;Mrsic-Flogel TD;Bonhoeffer T;Hübener M
通讯作者：
Hübener M