Closed-loop optogenetic perturbation of macaque oculomotor cerebellum: evidence for an internal saccade model.
Closed-loop optogenetic perturbation of macaque oculomotor cerebellum: evidence for an internal saccade model.
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猕猴动眼小脑的闭环光遗传学扰动：内部眼跳模型的证据。
DOI：
10.1101/2023.06.22.546199
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Horwitz,GregoryD
中科院分区：
文献类型：
--
作者：
Soetedjo,Robijanto;Horwitz,GregoryD
内部模型对于产生准确的动作是必不可少的。眼球跳动的准确性被认为是由小脑编码的眼球运动机制的内部模型所调节的。小脑也可能是反馈环路的一部分，该环路预测眼睛的移位，并实时将其与期望的移位进行比较，以确保眼跳落在目标上。为了研究小脑在这两个方面的眼跳产生中的作用，我们将眼跳触发的光脉冲传递到两只雄性猕猴的动眼蠕虫(OMV)中表达视紫红质-2的浦肯野细胞。在自发性眼跳的加速阶段发出的光脉冲减缓了减速阶段。这些效应的长潜伏期及其随光脉冲持续时间的变化与刺激部位或刺激部位下游的神经信号的整合是一致的。相比之下，在对比性眼跳过程中发出的光脉冲在短潜伏期降低了眼跳速度，随后是补偿性再加速，导致凝视落在目标上或附近。我们的结论是，OMV对眼跳产生的贡献取决于扫视方向；同侧OMV是预测眼睛位移的正向模型的一部分，而对侧OMV是反向模型的一部分，该模型创建了以预期位移的最佳峰值速度移动眼睛所需的力。
Internal models are essential for the production of accurate movements. The accuracy of saccadic eye movements is thought to be mediated by an internal model of oculomotor mechanics encoded in the cerebellum. The cerebellum may also be part of a feedback loop that predicts the displacement of the eyes and compares it to the desired displacement in real time to ensure that saccades land on target. To investigate the role of the cerebellum in these two aspects of saccade production, we delivered saccade-triggered light pulses to channelrhodopsin-2-expressing Purkinje cells in the oculomotor vermis (OMV) of two male macaque monkeys. Light pulses delivered during the acceleration phase of ipsiversive saccades slowed the deceleration phase. The long latency of these effects and their scaling with light pulse duration are consistent with an integration of neural signals at or downstream of the stimulation site. In contrast, light pulses delivered during contraversive saccades reduced saccade velocity at short latency and were followed by a compensatory reacceleration which caused gaze to land on or near the target. We conclude that the contribution of the OMV to saccade production depends on saccade direction; the ipsilateral OMV is part of a forward model that predicts eye displacement, whereas the contralateral OMV is part of an inverse model that creates the force required to move the eyes with optimal peak velocity for the intended displacement.
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影响因子：
2.5
作者：
OPTICAN, LM;MILES, FA
通讯作者：
MILES, FA
影响因子：
5.5
作者：
FUCHS, AF;LUSCHEI, ES
通讯作者：
LUSCHEI, ES
影响因子：
2.5
作者：
Takagi, M;Zee, DS;Tamargo, RJ
通讯作者：
Tamargo, RJ
有证据表明上丘参与眼球扫视运动的反馈控制。
DOI：
10.1152/jn.00886.2000
发表时间：
2002
期刊：
Journal of neurophysiology.
影响因子：
--
作者：
Soetedjo,Robijanto;Kaneko,ChrisRS;Fuchs,AlbertF
通讯作者：
Fuchs,AlbertF
影响因子：
5.3
作者：
Prsa, Mario;Dash, Suryadeep;Thier, Peter
通讯作者：
Thier, Peter