Bmc Musculoskeletal Disorders Elevated Levels of Β-catenin and Fibronectin in Three-dimensional Collagen Cultures of Dupuytren's Disease Cells Are Regulated by Tension in Vitro

Bmc Musculoskeletal Disorders Elevated Levels of Β-catenin and Fibronectin in Three-dimensional Collagen Cultures of Dupuytren's Disease Cells Are Regulated by Tension in Vitro
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Bmc 肌肉骨骼疾病 掌腱膜挛缩症细胞三维胶原培养物中 β-连环蛋白和纤连蛋白水平升高受体外张力调节

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通讯作者:
Siang Gan
Siang Gan
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作者:
J. Howard;Vincenzo M Varallo;D. Ross;J. Roth;K. Faber;B. Alman;B. Gan;Vincenzo M;Douglas;James H;Roth;Kenneth;Benjamin;Alman;Siang Gan

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背景:Dupuytren肌挛缩或疾病(DD)是一种手部纤维增生性疾病,导致在特定的掌侧筋膜带内形成疤痕样的富含胶原的疾病索带。虽然DD的分子病理机制尚不清楚,但最近的证据表明β-连环蛋白可能在其中起作用。在这项研究中,原发疾病成纤维细胞的胶原基质培养显示出增强的收缩和等长张力依赖的β-连环蛋白和纤维连接蛋白水平的变化。
Background: Dupuytren's contracture or disease (DD) is a fibro-proliferative disease of the hand that results in the development of scar-like, collagen-rich disease cords within specific palmar fascia bands. Although the molecular pathology of DD is unknown, recent evidence suggests that β-catenin may play a role. In this study, collagen matrix cultures of primary disease fibroblasts show enhanced contraction and isometric tension-dependent changes in β-catenin and fibronectin levels.
DOI: --
发表时间: 2000
期刊: --
影响因子: --
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