Impact of nicotine, alcohol, and cocaine exposure on germline integrity and epigenome.
Impact of nicotine, alcohol, and cocaine exposure on germline integrity and epigenome.
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DOI：
10.1016/j.neuropharm.2020.108127
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发表时间：
2020-08-15
影响因子：
4.7
通讯作者：
Gould TJ
中科院分区：
文献类型：
--
作者：
Zeid D;Gould TJ
综合证据表明，父母接触滥用药物会影响后代的表型。药物滥用对生殖细胞质量的影响可能会介导多代和跨代遗传，尽管这种遗传模式背后的生物学途径尚未得到表征。种系表观遗传标记通过药物暴露而改变，并在最近的工作中成为有希望的候选机制。药物暴露也会影响整体种系完整性和生殖功能，尽管这些后果在多代/跨代遗传中的作用尚不清楚。这篇综述综合了关于暴露于酒精、可卡因和尼古丁对种系的影响的文献，重点是药物暴露后的表观遗传修饰以及对种系完整性和生殖功能的更广泛影响。我们讨论了生殖功能、种系完整性和种系表观基因组/转录组之间在多代/跨代遗传途径中的潜在相互作用。我们发现现有数据可能支持这些种系影响对后代表型的独立或交互贡献，其方式可能介导多代/跨代遗传。
Converging evidence suggests that parental exposure to drugs of abuse can affect offspring phenotypes. The impacts of drug abuse on germ cell quality may mediate multigenerational and transgenerational inheritance, although biological pathways underlying this mode of inheritance are not yet characterized. Germline epigenetic marks are modified by drug exposure and have emerged as promising mechanistic candidates in recent work. Drug exposure also impacts overall germline integrity and reproductive functioning, although the role of these consequences in multi/transgenerational inheritance is unclear. This review synthesizes literature on effects of exposure to alcohol, cocaine, and nicotine on the germline with a focus on epigenetic modifications following drug exposure and broader impacts on germline integrity and reproductive functioning. We discuss potential interactions between reproductive functioning, germline integrity, and germline epigenome/transcriptome in pathways underlying multi/transgenerational inheritance. We find that existing data may support independent or interactive contributions of these germline impacts on offspring phenotypes in a manner that may mediate multi/transgenerational inheritance.
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影响因子：
64.5
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