Beta-alanine (Carnosyn™) supplementation in elderly subjects (60-80 years): effects on muscle carnosine content and physical capacity.
Beta-alanine (Carnosyn™) supplementation in elderly subjects (60-80 years): effects on muscle carnosine content and physical capacity.
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DOI：
10.1007/s00726-011-1190-x
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发表时间：
2012-07
期刊：
影响因子：
3.5
通讯作者：
Gualano, Bruno
中科院分区：
文献类型：
--
作者：
del Favero, Serena;Roschel, Hamilton;Solis, Marina Y.;Hayashi, Ana P.;Artioli, Guilherme G.;Otaduy, Maria Concepcion;Benatti, Fabiana B.;Harris, Roger C.;Wise, John A.;Leite, Claudia C.;Pereira, Rosa M.;de Sa-Pinto, Ana L.;Lancha-Junior, Antonio Herbert;Gualano, Bruno
本研究旨在探讨补充β-丙氨酸对老年人运动能力和肌肉肌肽含量的影响。18名健康老年受试者（60-80岁，10名女性和4名男性）被随机分配接受β-丙氨酸（BA，n = 12）或安慰剂（PL，n = 6）治疗12周。BA组每天接受3.2 g β-丙氨酸（2 × 800 mg缓释Carnosyn™片剂，每天给药2次）。PL组接受2 ×（2 × 800 mg）匹配安慰剂。在基线（PRE）和补充12周后（POST-12），对肌肉肌肽含量、无氧运动能力、肌肉功能、生活质量、身体活动和食物摄入进行评估。与PL组（+7.2%）相比，BA组（+85.4%）的腓肠肌肌肽含量显著增加（p = 0.004; ES：1.21）。恒定负荷次最大试验中的至力竭时间（即，BA组（+36.5%）与PL组（+8.6%）相比，TLIM显著改善（p = 0.05; ES：1.71）。类似地，与安慰剂（+0.1%）相比，补充β-丙氨酸（+12.2%）后，增量试验中的至力竭时间也显著增加（p = 0.04; ES 1.03）。在TLIM测试（r = 0.62; p = 0.01）和增量测试（r = 0.48; p = 0.02）中，肌肉肌肽含量的相对变化与至力竭时间的相对变化之间也显示出显著的正相关性。总之，目前的数据首次表明，β-丙氨酸补充剂在增加健康老年受试者的肌肉肌肽含量方面是有效的，随后改善了他们的运动能力。
The aim of this study was to investigate the effects of beta-alanine supplementation on exercise capacity and the muscle carnosine content in elderly subjects. Eighteen healthy elderly subjects (60–80 years, 10 female and 4 male) were randomly assigned to receive either beta-alanine (BA, n = 12) or placebo (PL, n = 6) for 12 weeks. The BA group received 3.2 g of beta-alanine per day (2 × 800 mg sustained-release Carnosyn™ tablets, given 2 times per day). The PL group received 2 × (2 × 800 mg) of a matched placebo. At baseline (PRE) and after 12 weeks (POST-12) of supplementation, assessments were made of the muscle carnosine content, anaerobic exercise capacity, muscle function, quality of life, physical activity and food intake. A significant increase in the muscle carnosine content of the gastrocnemius muscle was shown in the BA group (+85.4%) when compared with the PL group (+7.2%) (p = 0.004; ES: 1.21). The time-to-exhaustion in the constant-load submaximal test (i.e., TLIM) was significantly improved (p = 0.05; ES: 1.71) in the BA group (+36.5%) versus the PL group (+8.6%). Similarly, time-to-exhaustion in the incremental test was also significantly increased (p = 0.04; ES 1.03) following beta-alanine supplementation (+12.2%) when compared with placebo (+0.1%). Significant positive correlations were also shown between the relative change in the muscle carnosine content and the relative change in the time-to-exhaustion in the TLIM test (r = 0.62; p = 0.01) and in the incremental test (r = 0.48; p = 0.02). In summary, the current data indicate for the first time, that beta-alanine supplementation is effective in increasing the muscle carnosine content in healthy elderly subjects, with subsequent improvement in their exercise capacity.
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影响因子：
4.9
作者：
Madureira, Melisa M.;Bonfa, Eloisa;Pereira, Rosa M. R.
通讯作者：
Pereira, Rosa M. R.
影响因子：
3.5
作者：
Kim, Hyo-Jeong
通讯作者：
Kim, Hyo-Jeong
影响因子：
4.1
作者：
Sale, Craig;Saunders, Bryan;Sunderland, Caroline D.
通讯作者：
Sunderland, Caroline D.
DOI：
10.1186/1550-2783-5-21
发表时间：
2008-11-07
影响因子：
5.1
作者：
Stout, Jeffrey R.;Graves, B. Sue;Harris, Roger C.
通讯作者：
Harris, Roger C.
影响因子：
4
作者：
Stuerenburg, HJ;Kunze, K
通讯作者：
Kunze, K