Spread through Air Spaces (STAS) Is an Independent Predictor of Recurrence and Lung Cancer-Specific Death in Squamous Cell Carcinoma.
Spread through Air Spaces (STAS) Is an Independent Predictor of Recurrence and Lung Cancer-Specific Death in Squamous Cell Carcinoma.
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通过空气空间传播 (STAS) 是鳞状细胞癌复发和肺癌特异性死亡的独立预测因素
DOI：
10.1016/j.jtho.2016.09.129
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发表时间：
2017-03
期刊：
影响因子：
--
通讯作者：
Travis WD
中科院分区：
文献类型：
--
作者：
Lu S;Tan KS;Kadota K;Eguchi T;Bains S;Rekhtman N;Adusumilli PS;Travis WD
气隙扩散（STAS）是最近认识到的肺腺癌的浸润模式，然而，它尚未在鳞状细胞癌（SCC）中得到表征。我们回顾了445例手术切除的I-III期肺鳞癌，并探讨了STAS的临床意义。通过竞争风险分析评估累积复发率（CIR）和肺癌特异性死亡（CID），并通过考克斯模型评估总生存期（OS）。在总共445名患者中，336名（76%）年龄>65岁。在273例死亡患者中，91例（33%）死于肺癌，其余患者死于竞争性事件或不明原因。132例患者（30%）观察到STAS，且频率随分期增加而增加。与无STAS的患者相比，STAS患者的任何远处和局部复发以及肺癌特异性死亡的累积发生率显著较高，而OS无统计学显著差异。在任何复发和肺癌特异性死亡的多变量模型中，STAS是两种结局的独立预测因子（分别为p=0.034和0.016）。三分之一切除的肺SCC中存在STAS。在一个队列的竞争风险分析中，四分之三的患者是老年人，STAS与肺癌特异性结局相关。我们的研究结果表明，STAS是肺SCC中最具诊断意义的组织学表现之一。
Spread through air spaces (STAS) is a recently recognized pattern of invasion in lung adenocarcinoma, however, it has not yet been characterized in squamous cell carcinoma (SCC). We reviewed 445 resected stage I-III lung SCC and investigated the clinical significance of STAS. Cumulative incidence of recurrence (CIR) and lung cancer-specific death (CID) were evaluated by competing risks analyses and overall survival (OS) by Cox models. Of total 445 patients, 336 (76%) were >65 years old. Among 273 patients who died, 91 (33%) died of lung cancer whereas the remaining died of competing events or unknown cause. STAS was observed in 132 patients (30%) and the frequency increased with stage. The cumulative incidence of any, distant, and locoregional recurrence as well as lung cancer-specific death were significantly higher in patients with STAS compared to those without STAS, whereas there was no statistically significant difference in OS. In multivariable models for any recurrence and lung cancer-specific death, STAS was an independent predictor for both outcomes (p=0.034 and 0.016, respectively). STAS was present in one third of resected lung SCC. In competing risks analysis in a cohort where three fourths of the patients were elderly, STAS was associated with lung cancer-specific outcomes. Our findings suggest that STAS is one of the most prognostically significant histologic findings in lung SCC.
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影响因子：
3.5
作者：
Layfield, Lester J.;Witt, Benjamin L.;Anderson, Gina M.
通讯作者：
Anderson, Gina M.
影响因子：
5.3
作者：
Taira, Tetsuhiko;Ishii, Genichiro;Ochiai, Atsushi
通讯作者：
Ochiai, Atsushi
影响因子：
5.6
作者：
Warth, Arne;Muley, Thomas;Weichert, Wilko
通讯作者：
Weichert, Wilko
影响因子：
5.6
作者：
Warth, Arne;Muley, Thomas;Weichert, Wilko
通讯作者：
Weichert, Wilko
DOI：
10.1158/1078-0432.ccr-11-2097
发表时间：
2012-04-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Dignam JJ;Zhang Q;Kocherginsky M
通讯作者：
Kocherginsky M