Household environmental conditions are associated with enteropathy and impaired growth in rural Bangladesh.
Household environmental conditions are associated with enteropathy and impaired growth in rural Bangladesh.
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DOI：
10.4269/ajtmh.12-0629
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发表时间：
2013-07
期刊：
影响因子：
--
通讯作者：
Luby SP
中科院分区：
文献类型：
--
作者：
Lin A;Arnold BF;Afreen S;Goto R;Huda TMN;Haque R;Raqib R;Unicomb L;Ahmed T;Colford JM;Luby SP
我们评估粪便环境污染与环境性肠病的关系。我们比较了孟加拉国农村地区119名孟加拉国儿童（≤ 48个月）的环境肠病、寄生虫负担和生长指标，这些儿童生活在由水质、卫生和洗手基础设施的客观指标定义的不同家庭环境清洁水平中。校正潜在混杂特征后，来自清洁家庭的儿童与来自污染家庭的儿童相比，身高年龄比z评分（HAZ）高0.54 SD（95%置信区间[CI] = 0.06，1.01），尿液中乳果糖：甘露醇（L：M）比低0.32 SD（95% CI = −0.72，0.08），免疫球蛋白G内毒素核心抗体（IgG EndoCAb）滴度低0.24 SD（95% CI = −0.63，0.16）。校正年龄和性别后，ln L：M增加1个单位与HAZ降低0.33 SD相关（95% CI =-0.62，-0.05）。这些结果与环境污染导致通过环境肠病介导的生长停滞的假设一致。
We assessed the relationship of fecal environmental contamination and environmental enteropathy. We compared markers of environmental enteropathy, parasite burden, and growth in 119 Bangladeshi children (≤ 48 months of age) across rural Bangladesh living in different levels of household environmental cleanliness defined by objective indicators of water quality and sanitary and hand-washing infrastructure. Adjusted for potential confounding characteristics, children from clean households had 0.54 SDs (95% confidence interval [CI] = 0.06, 1.01) higher height-for-age z scores (HAZs), 0.32 SDs (95% CI = −0.72, 0.08) lower lactulose:mannitol (L:M) ratios in urine, and 0.24 SDs (95% CI = −0.63, 0.16) lower immunoglobulin G endotoxin core antibody (IgG EndoCAb) titers than children from contaminated households. After adjusting for age and sex, a 1-unit increase in the ln L:M was associated with a 0.33 SDs decrease in HAZ (95% CI = −0.62, −0.05). These results are consistent with the hypothesis that environmental contamination causes growth faltering mediated through environmental enteropathy.
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影响因子：
5
作者：
ESREY, SA;HABICHT, JP;CASELLA, G
通讯作者：
CASELLA, G
影响因子：
24.5
作者：
Menzies, IS;Zuckerman, MJ;Gregory, GG
通讯作者：
Gregory, GG
影响因子：
1.8
作者：
Freedman, David A.
通讯作者：
Freedman, David A.
影响因子：
3.6
作者：
Campbell, DI;Murch, SH;Lunn, PG
通讯作者：
Lunn, PG
DOI：
10.1016/j.trstmh.2008.07.020
发表时间：
2009-05-01
影响因子：
2.2
作者：
Goto, Rie;Mascie-Taylor, C. G. Nicholas;Lunn, Peter G.
通讯作者：
Lunn, Peter G.