The effect of hOGG1 Ser326Cys polymorphism on cancer risk: evidence from a meta-analysis.
The effect of hOGG1 Ser326Cys polymorphism on cancer risk: evidence from a meta-analysis.
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HOGG1 Ser326Cys多态性对癌症风险的影响：荟萃分析的证据。
DOI：
10.1371/journal.pone.0027545
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Lu P
中科院分区：
文献类型：
--
作者：
Wei B;Zhou Y;Xu Z;Xi B;Cheng H;Ruan J;Zhu M;Hu Q;Wang Q;Wang Z;Yan Z;Jin K;Zhou D;Xuan F;Huang X;Shao J;Lu P
碱基切除修复 (BER) 途径中的人氧鸟嘌呤糖基化酶 1 (hOGG1) 在 DNA 修复中发挥着至关重要的作用。许多流行病学研究评估了 hOGG1 Ser326Cys 多态性与癌症风险之间的关联。然而，这些关于这种关联的研究结果仍然相互矛盾。为了对这种关联进行更精确的估计，我们进行了荟萃分析。进行了全面检索以确定 hOGG1 Ser326Cys 多态性和癌症风险的合格研究。我们使用比值比 (OR) 和 95% 置信区间 (CI) 来评估关联的强度。我们发现 hOGG1 Ser326Cys 多态性与总体癌症风险显着相关（Cys/Cys 与 Ser/Ser：OR = 1.19，95%CI = 1.09–1.30，P<0.001；Cys/Cys 与 Cys/Ser+Ser/Ser：OR = 1.16， 95%CI = 1.08–1.26, P<0.001)。此外，在按癌症类型进行的亚组分析中，发现hOGG1 Ser326Cys多态性与肺癌风险之间存在更强的显着相关性（Cys/Cys vs. Ser/Ser：OR = 1.29，95%CI = 1.16–1.44，P<0.001；Cys/Cys vs. Cys/Ser+Ser/Ser： OR = 1.22，95%CI = 1.12–1.33，P<0.001）。未检测到hOGG1 Ser326Cys多态性对结直肠癌、乳腺癌、膀胱癌、前列腺癌、食管癌和胃癌的显着影响。此外，在按种族进行的亚组分析中，我们发现hOGG1 Ser326Cys多态性与亚洲人的总体癌症风险相关（Cys/Cys vs. Ser/Ser：OR = 1.21，95%CI = 1.10–1.33，P<0.001）。这项荟萃分析表明 hOGG1 326Cys 等位基因可能是肺癌的低渗透危险因素。
Human oxoguanine glycosylase 1 (hOGG1) in base excision repair (BER) pathway plays a vital role in DNA repair. Numerous epidemiological studies have evaluated the association between hOGG1 Ser326Cys polymorphism and the risk of cancer. However, the results of these studies on the association remain conflicting. To derive a more precise estimation of the association, we conducted a meta-analysis. A comprehensive search was conducted to identify the eligible studies of hOGG1 Ser326Cys polymorphism and cancer risk. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association. We found that the hOGG1 Ser326Cys polymorphism was significantly associated with overall cancer risk (Cys/Cys vs. Ser/Ser: OR = 1.19, 95%CI = 1.09–1.30, P<0.001; Cys/Cys vs. Cys/Ser+Ser/Ser: OR = 1.16, 95%CI = 1.08–1.26, P<0.001). Moreover, in subgroup analyses by cancer types, the stronger significant association between hOGG1 Ser326Cys polymorphism and lung cancer risk was found (Cys/Cys vs. Ser/Ser: OR = 1.29, 95%CI = 1.16–1.44, P<0.001; Cys/Cys vs. Cys/Ser+Ser/Ser: OR = 1.22, 95%CI = 1.12–1.33, P<0.001). The significant effects of hOGG1 Ser326Cys polymorphism on colorectal, breast, bladder, prostate, esophageal, and gastric cancer were not detected. In addition, in subgroup analyses by ethnicities, we found that the hOGG1 Ser326Cys polymorphism was associated with overall cancer risk in Asians (Cys/Cys vs. Ser/Ser: OR = 1.21, 95%CI = 1.10–1.33, P<0.001). This meta-analysis showed that hOGG1 326Cys allele might be a low-penetrant risk factor for lung cancer.
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影响因子：
5.3
作者：
Figueroa, Jonine D.;Malats, Nuria;Garcia-Closas, Montserrat
通讯作者：
Garcia-Closas, Montserrat
影响因子：
5
作者：
Chang, Chin-Hao;Hsiao, Chin-Fu;Hsiung, Chao A.
通讯作者：
Hsiung, Chao A.
DOI：
10.1016/j.ijrobp.2004.12.027
发表时间：
2005-07-15
影响因子：
7
作者：
De Ruyck, K;Van Eijkeren, M;Thierens, H
通讯作者：
Thierens, H
影响因子：
7.7
作者：
Capella, Gabriel;Pera, Guillem;Gonzalez, Carlos A.
通讯作者：
Gonzalez, Carlos A.
影响因子：
6.6
作者：
Chen, L;Elahi, A;Park, J
通讯作者：
Park, J