Long-chain n-3 and n-6 polyunsaturated fatty acids and risk of atrial fibrillation: Results from a Danish cohort study.
Long-chain n-3 and n-6 polyunsaturated fatty acids and risk of atrial fibrillation: Results from a Danish cohort study.
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DOI：
10.1371/journal.pone.0190262
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Overvad K
中科院分区：
文献类型：
--
作者：
Mortensen LM;Lundbye-Christensen S;Schmidt EB;Calder PC;Schierup MH;Tjønneland A;Parner ET;Overvad K
关于多不饱和脂肪酸与房颤风险之间关系的研究尚无定论。房颤的风险可能取决于n-3和n-6多不饱和脂肪酸之间的相互作用，因为这两种脂肪酸都参与全身性炎症的调节。我们研究了饮食摄入长链多不饱和脂肪酸（单独和联合）与房颤风险之间的关系，重点研究了两种多不饱和脂肪酸之间的潜在相互作用。采用伪观察法对饮食、癌症和健康队列中的房颤风险进行分析，在提供风险差异的累加量表上探索累积风险。采用食物频度问卷法评估长链多不饱和脂肪酸的膳食摄入量。为了考虑长链多不饱和脂肪酸的内源性合成，对日粮中n-3 α-亚麻酸和n-6亚油酸的摄入量进行了调整。相互作用被评估为绝对关联测量的可加性偏差（风险差异）。在队列的三个阶层（N = 54,737）中估计了15岁年龄段的累积风险。摄入n-3或n-6长链多不饱和脂肪酸与房颤之间没有关联，无论是作为主要暴露单独分析，还是研究n-3和n-6长链多不饱和脂肪酸之间的相互作用。本研究提示摄入长链多不饱和脂肪酸与房颤风险之间无关联。
Studies of the relation between polyunsaturated fatty acids and risk of atrial fibrillation have been inconclusive. The risk of atrial fibrillation may depend on the interaction between n-3 and n-6 polyunsaturated fatty acids as both types of fatty acids are involved in the regulation of systemic inflammation. We investigated the association between dietary intake of long chain polyunsaturated fatty acids (individually and in combination) and the risk of atrial fibrillation with focus on potential interaction between the two types of polyunsaturated fatty acids. The risk of atrial fibrillation in the Diet, Cancer and Health Cohort was analyzed using the pseudo-observation method to explore cumulative risks on an additive scale providing risk differences. Dietary intake of long chain polyunsaturated fatty acids was assessed by food frequency questionnaires. The main analyses were adjusted for the dietary intake of n-3 α-linolenic acid and n-6 linoleic acid to account for endogenous synthesis of long chain polyunsaturated fatty acids. Interaction was assessed as deviation from additivity of absolute association measures (risk differences). Cumulative risks in 15-year age periods were estimated in three strata of the cohort (N = 54,737). No associations between intake of n-3 or n-6 long chain polyunsaturated fatty acids and atrial fibrillation were found, neither when analyzed separately as primary exposures nor when interaction between n-3 and n-6 long chain polyunsaturated fatty acids was explored. This study suggests no association between intake of long chain polyunsaturated fatty acids and risk of atrial fibrillation.
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