Weight Loss Interventions and Skeletal Health in Persons with Diabetes.
Weight Loss Interventions and Skeletal Health in Persons with Diabetes.
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DOI：
10.1007/s11914-022-00744-9
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发表时间：
2022-10
影响因子：
4.3
通讯作者：
中科院分区：
文献类型：
--
作者：
减肥被推荐用于改善糖尿病患者的血糖控制和减少心血管危险因素。然而，糖尿病和体重减轻都与有害的骨骼健康有关。本文综述了近年来关于生活方式干预减肥对2型糖尿病（T2D）患者骨骼健康影响的研究结果。一些大规模的观察性研究表明，T2D患者中与体重减轻相关的脆性骨折风险增加。在T2D患者中进行的随机对照试验也表明，减肥的有意生活方式干预与骨矿物质密度（BMD）的更大下降和骨折风险的增加有关。在减肥的生活方式干预过程中损害骨骼健康的生物学机制是复杂的，尚未得出结论。然而，有证据表明，在有意减肥过程中，骨丢失和骨折风险增加可能会通过一些干预措施来缓解，例如高蛋白质摄入，钙补充以及阻力和平衡训练。仍然缺乏研究调查不同的减肥干预措施对T2D患者骨骼健康的影响。然而，某些类型的饮食和体力活动干预结合骨监测和骨折风险预测可能有助于实现减肥目标，并在有意减肥期间维持T2D患者的骨骼健康。
Weight loss is recommended for improving glycemic control and reducing cardiovascular risk factors in persons with diabetes. However, both diabetes and weight loss have been associated with detrimental skeletal health. This review aims to summarize recent study findings on the effects of lifestyle interventions for weight loss on skeletal health among persons with type 2 diabetes (T2D). A few large-scale observational studies have demonstrated an increased fragility fracture risk associated with weight loss among persons with T2D. Randomized control trials in persons with T2D also have shown that intentional lifestyle interventions for weight loss are associated with a greater decrease in bone mineral density (BMD) and an increase in the risk of fracture. The biological mechanisms underlying the compromised bone health during lifestyle interventions for weight loss are complex and not yet conclusive. However, there is evidence to suggest that bone loss and increased fracture risk during intentional weight loss may be mitigated by some intervention approaches, such as high protein intake, calcium supplementation, and resistance and balance training. There is still a lack of studies investigating the effects of different interventions for weight loss on skeletal health among persons with T2D. However, certain types of diet and physical activity intervention combined with bone monitoring and fracture risk prediction may help achieve weight loss goals and maintain skeletal health among persons with T2D during intentional weight loss.
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影响因子：
44.5
作者：
Gregg, Edward W.;Jakicic, John M.;Lewis, Cora E.;Regensteiner, Judith G.;Pi-Sunyer, Xavier;Wing, Rena R.;Curtis, Jeffrey M.;Yanovski, Susan Z.;Evans, Mary;Lang, Wei;Neiberg, Rebecca H.;Ribisl, Paul M.;Gregg, Edward W.;Jakicic, John M.;Blackburn, George;Bloomquist, Paul;Bray, George A.;Clark, Jeanne M.;Coday, Mace;Curtis, Jeff Rey M.;Egan, Caitlin;Evans, Mary;Foreyt, John P.;Foster, Gary D.;Hazuda, Helen P.;Hill, James O.;Horton, Edward S.;Hubbard, Van S.;Ery, Robert W. Jeff;Johnson, Karen C.;Abbas;Kitabchi;Knowler, William C.;Kriska, Andrea;Lang, Wei;Lewis, Cora E.;Montez, Maria G.;Nathan, David M.;Neiberg, Rebecca H.;Patricio, Jennifer;Peters, Anne;Pi-Sunyer, Xavier;Pownall, Henry;Redmon, Bruce;Regensteiner, Judith G.;Rejeski, W. Jack;Ribisl, Paul M.;Ord, Monika Saff;Stewart, Kerry;Trence, Dace;Wadden, Thomas A.;Wing, Rena R.;Yanovski, Susan Z.
通讯作者：
Yanovski, Susan Z.
DOI：
10.1002/jbmr.4466
发表时间：
2022-03
期刊：
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
影响因子：
--
作者：
Dhaliwal R;Ewing SK;Vashishth D;Semba RD;Schwartz AV
通讯作者：
Schwartz AV
DOI：
10.1046/j.1532-5415.2003.51558.x
发表时间：
2003-12-01
影响因子：
6.3
作者：
Ensrud, KE;Ewing, SK;Cummings, SR
通讯作者：
Cummings, SR
影响因子：
158.5
作者：
Hu, FB;Manson, JE;Willett, WC
通讯作者：
Willett, WC
肥胖患者因代谢手术或生活方式干预而减肥后骨矿物质密度的变化
影响因子：
2.9
作者：
Chen, Xi;Zhang, Jingjing;Zhou, Zhiguang
通讯作者：
Zhou, Zhiguang