Predictive clinical factors of cystoid macular edema in patients with Descemet's stripping automated endothelial keratoplasty.
Predictive clinical factors of cystoid macular edema in patients with Descemet's stripping automated endothelial keratoplasty.
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DOI：
10.1038/s41598-017-07079-x
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发表时间：
2017-08-07
影响因子：
4.6
通讯作者：
Kinoshita S
中科院分区：
文献类型：
--
作者：
Kitazawa K;Kayukawa K;Wakimasu K;Yokota I;Inatomi T;Hieda O;Mori K;Sotozono C;Kinoshita S
本研究的目的是在一个大型病例系列中调查后弹力层剥脱式自动内皮角膜移植术（DSAEK）后黄斑囊样水肿（CME）的预测临床因素。在2011年7月至2016年11月期间在日本京都Baptist眼科研究所接受DSAEK的393例连续患者中，入组了241例术前或术后早期未发生CME的患者。通过光学相干断层扫描（OCT）前瞻性检查解剖CME的发生。采用多因素Logistic回归分析可能的临床预测因素。DSAEK后1个月，241例患者中有27例（11.2%）发生CME。多因素分析显示原发性闭角型青光眼（PACG）与术后CME显著相关（优势比= 6.4，P = 0.04）。本研究的结果显示，PACG患者的DSAEK显示CME的发生率较高，因此，应通过OCT对他们进行仔细的黄斑术后观察。
The purpose of this present study was to investigate predictive clinical factors associated with cystoid macular edema (CME) post Descemet’s stripping automated endothelial keratoplasty (DSAEK) in a large case series. Of 393 consecutive patients who underwent DSAEK at Baptist Eye Institute, Kyoto, Japan between July 2011 and November 2016, 241 patients without CME at the pre- or early-postoperative periods were enrolled. The occurrence of anatomic CME was prospectively examined via optical coherence tomography (OCT). Possible predictive clinical factors for CME were analyzed by multivariate logistic regression analysis. At 1-month post DSAEK, CME occurred in 27 (11.2%) of the 241 patients. Multivariate analysis revealed that primary angle closure glaucoma (PACG) was significantly associated with postoperative CME (odds ratio = 6.4, P = 0.04). The findings of this study revealed that DSAEK in patients with PACG showed a high incidence of CME, thus indicating that they should undergo a careful postoperative observation of the macula via OCT.
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