Adaptive training diminishes distractibility in aging across species.
Adaptive training diminishes distractibility in aging across species.
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DOI：
10.1016/j.neuron.2014.10.034
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发表时间：
2014-12-03
期刊：
影响因子：
16.2
通讯作者：
Gazzaley, Adam
中科院分区：
文献类型：
--
作者：
Mishra, Jyoti;de Villers-Sidani, Etienne;Merzenich, Michael;Gazzaley, Adam
Aging is associated with deficits in the ability to ignore distractions, which has not yet been remediated by any neurotherapeutic approach. Here, in parallel auditory experiments with older rats and humans, we evaluated a targeted cognitive training approach that adaptively manipulated distractor challenge. Training resulted in enhanced discrimination abilities in the setting of irrelevant information in both species that was driven by selectively diminished distraction-related errors. Neural responses to distractors in auditory cortex were selectively reduced in both species mimicking the behavioral effects. Sensory receptive fields in trained rats exhibited improved spectral and spatial selectivity. Frontal theta measures of top-down engagement with distractors were selectively restrained in trained humans. Finally, training gains generalized to group- and individual-level benefits in aspects of working memory and sustained attention. Thus, we demonstrate converging cross-species evidence for training-induced selective plasticity of distractor processing at multiple neural scales, benefitting distractor suppression and cognitive control.
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影响因子：
3.7
作者：
Berry AS;Zanto TP;Clapp WC;Hardy JL;Delahunt PB;Mahncke HW;Gazzaley A
通讯作者：
Gazzaley A
影响因子：
1.8
作者：
Betts, Lisa R.;Sekuler, Allison B.;Bennett, Patrick J.
通讯作者：
Bennett, Patrick J.
影响因子：
16.6
作者：
Chadick, James Z.;Zanto, Theodore P.;Gazzaley, Adam
通讯作者：
Gazzaley, Adam
DOI：
10.1073/pnas.1213555110
发表时间：
2013-03-12
影响因子：
11.1
作者：
Anderson, Samira;White-Schwoch, Travis;Kraus, Nina
通讯作者：
Kraus, Nina
DOI：
10.1073/pnas.1007885107
发表时间：
2010-08-03
影响因子：
11.1
作者：
de Villers-Sidani, Etienne;Alzghoul, Loai;Merzenich, Michael M.
通讯作者：
Merzenich, Michael M.