Evolution of Salmonella-Host Cell Interactions through a Dynamic Bacterial Genome.
Evolution of Salmonella-Host Cell Interactions through a Dynamic Bacterial Genome.
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DOI：
10.3389/fcimb.2017.00428
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发表时间：
2017
影响因子：
5.7
通讯作者：
Coombes BK
中科院分区：
文献类型：
--
作者：
Ilyas B;Tsai CN;Coombes BK
鼠伤寒沙门氏菌拥有广泛的基因库，这些基因受到严格调控和协调，以促进其适应其定殖的各种宿主环境。鼠伤寒沙门氏菌的基因组经历了多次基因获取事件，并且非编码 DNA 发生了变化，这些变化经历了调控进化的选择。至少 17 个水平获得性致病岛 (SPI)、原噬菌体相关基因以及核心基因组调控的变化共同促成了沙门氏菌的毒力程序。在这里，我们回顾了对这些元件及其对发病机制的贡献的最新理解，强调了控制生态位特异性基因表达的调节电路。除了概述 SPI-1 和 SPI-2 对宿主入侵和定植的重要性外，我们还描述了其他 SPI 最近的贡献，包括 SPI-6 的抗菌活性以及 SPI-4 介导的粘附和入侵。我们进一步讨论了如何通过顺式调节进化以及通过调节蛋白的沉默和反沉默的仔细平衡将这些适应性特征整合到细菌细胞的调节回路中。对沙门氏菌内部调控进化的详细了解揭示了与宿主-病原体相互作用和逃避宿主免疫相关的感染生物学的新方面。
Salmonella Typhimurium has a broad arsenal of genes that are tightly regulated and coordinated to facilitate adaptation to the various host environments it colonizes. The genome of Salmonella Typhimurium has undergone multiple gene acquisition events and has accrued changes in non-coding DNA that have undergone selection by regulatory evolution. Together, at least 17 horizontally acquired pathogenicity islands (SPIs), prophage-associated genes, and changes in core genome regulation contribute to the virulence program of Salmonella. Here, we review the latest understanding of these elements and their contributions to pathogenesis, emphasizing the regulatory circuitry that controls niche-specific gene expression. In addition to an overview of the importance of SPI-1 and SPI-2 to host invasion and colonization, we describe the recently characterized contributions of other SPIs, including the antibacterial activity of SPI-6 and adhesion and invasion mediated by SPI-4. We further discuss how these fitness traits have been integrated into the regulatory circuitry of the bacterial cell through cis-regulatory evolution and by a careful balance of silencing and counter-silencing by regulatory proteins. Detailed understanding of regulatory evolution within Salmonella is uncovering novel aspects of infection biology that relate to host-pathogen interactions and evasion of host immunity.
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影响因子：
15.9
作者：
Baumler, AJ
通讯作者：
Baumler, AJ
DOI：
10.1073/pnas.0505401102
发表时间：
2005-11-29
影响因子：
11.1
作者：
Coombes, BK;Wickham, ME;Finlay, BB
通讯作者：
Finlay, BB
影响因子：
3.1
作者：
Barthel, M;Hapfelmeier, S;Hardt, WD
通讯作者：
Hardt, WD
影响因子：
2.8
作者：
Aznar, Sonia;Paytubi, Sonia;Juarez, Antonio
通讯作者：
Juarez, Antonio
影响因子：
4.4
作者：
Blondel CJ;Jiménez JC;Contreras I;Santiviago CA
通讯作者：
Santiviago CA