Aqueous outflow channels and its lymphatic association: A review.
Aqueous outflow channels and its lymphatic association: A review.
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DOI：
10.1016/j.survophthal.2021.10.004
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发表时间：
2022-05
影响因子：
5.1
通讯作者：
Wong, Tina T.
中科院分区：
文献类型：
--
作者：
Narayanaswamy, Arun;Thakur, Sahil;Nongpiur, Monisha E.;Schmetterer, Leopold;Hong, Young-Kwon;Huang, Alex S.;Wong, Tina T.
关键词：
人眼具有独特的免疫结构和行为。虽然已知结膜具有明确的淋巴引流系统，但角膜、巩膜和葡萄膜组织在历史上被认为是“淋巴的”并且被认为是免疫豁免的。房水流出通道沿着流出路径携带透明流体（房水）的事实使得难以忽视其类似晶状体的特征。新的淋巴谱系标志物的发展和这些标志物在房水流出通道中的表达以及成像能力的提高引发了对眼部炎症研究的新兴趣。过去十年，眼科淋巴研究发生了方向性转变，提供了一个令人兴奋的新生理平台，需要进一步深入了解。人类睫状体中存在不同淋巴通道的证据正在获得显著的牵引力。葡萄膜淋巴通路是一种新的房水流出途径，为青光眼的病理生理学和治疗增加了新的维度。开发新的动物模型，标记物和非侵入性成像工具来描绘核心解剖结构和生理功能，可能有助于铺平一些重要的途径来了解疾病的病理生理学，并有助于开发新的青光眼靶向治疗方法。
The human eye has a unique immune architecture and behavior. While the conjunctiva is known to have a well-defined lymphatic drainage system, the cornea, sclera, and uveal tissues were historically considered “alymphatic” and thought to be immune privileged. The very fact that the aqueous outflow channels carry a clear fluid (aqueous humor) along the outflow pathway makes it hard to ignore its lymphatic-like characteristics. The development of novel lymphatic lineage markers and expression of these markers in aqueous outflow channels and improved imaging capabilities has sparked a renewed interest in the study of ocular lymphatics. Ophthalmic lymphatic research has had a directional shift over the last decade, offering an exciting new physiological platform that needs further in-depth understanding. The evidence of a presence of distinct lymphatic channels in the human ciliary body is gaining significant traction. The uveolymphatic pathway is an alternative new route for aqueous outflow and adds a new dimension to pathophysiology and management of glaucoma. Developing novel animal models, markers, and non-invasive imaging tools to delineate the core anatomical structure and physiological functions may help pave some crucial pathways to understand disease pathophysiology and help develop novel targeted therapeutic approaches for glaucoma.
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