Persistent lung inflammation and fibrosis in serum amyloid P component (APCs-/-) knockout mice.
Persistent lung inflammation and fibrosis in serum amyloid P component (APCs-/-) knockout mice.
复制标题
DOI：
10.1371/journal.pone.0093730
复制
发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Gomer RH
中科院分区：
文献类型：
--
作者：
Pilling D;Gomer RH
Fibrosing diseases, such as pulmonary fibrosis, cardiac fibrosis, myelofibrosis, liver fibrosis, and renal fibrosis are chronic and debilitating conditions and are an increasing burden for the healthcare system. Fibrosis involves the accumulation and differentiation of many immune cells, including macrophages and fibroblast-like cells called fibrocytes. The plasma protein serum amyloid P component (SAP; also known as pentraxin-2, PTX2) inhibits fibrocyte differentiation in vitro, and injections of SAP inhibit fibrosis in vivo. SAP also promotes the formation of immuno-regulatory Mreg macrophages. To elucidate the endogenous function of SAP, we used bleomycin aspiration to induce pulmonary inflammation and fibrosis in mice lacking SAP. Compared to wildtype C57BL/6 mice, we find that in Apcs-/- “SAP knock-out” mice, bleomycin induces a more persistent inflammatory response and increased fibrosis. In both C57BL/6 and Apcs-/- mice, injections of exogenous SAP reduce the accumulation of inflammatory macrophages and prevent fibrosis. The types of inflammatory cells present in the lungs following bleomycin-aspiration appear similar between C57BL/6 and Apcs -/- mice, suggesting that the initial immune response is normal in the Apcs-/- mice, and that a key endogenous function of SAP is to promote the resolution of inflammation and fibrosis.
登录
查看更多内容
DOI：
10.1146/annurev-pathol-020712-163930
发表时间：
2013-01-24
期刊：
Annual review of pathology
影响因子：
--
作者：
Duffield JS;Lupher M;Thannickal VJ;Wynn TA
通讯作者：
Wynn TA
影响因子：
3.7
作者：
Cox N;Pilling D;Gomer RH
通讯作者：
Gomer RH
DOI：
10.1073/pnas.0608799103
发表时间：
2006-11-28
影响因子：
11.1
作者：
Haudek, Sandra B.;Xia, Ying;Entman, Mark L.
通讯作者：
Entman, Mark L.
DOI：
10.1164/rccm.201010-1719oc
发表时间：
2011-09-01
影响因子：
24.7
作者：
Gibbons, Michael A.;MacKinnon, Alison C.;Forbes, Stuart J.
通讯作者：
Forbes, Stuart J.
DOI：
10.1073/pnas.0804910105
发表时间：
2008-07-22
影响因子：
11.1
作者：
Haudek, Sandra B.;Trial, JoAnn;Entman, Mark L.
通讯作者：
Entman, Mark L.