Chaste: an open source C++ library for computational physiology and biology.
Chaste: an open source C++ library for computational physiology and biology.
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DOI：
10.1371/journal.pcbi.1002970
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发表时间：
2013
影响因子：
4.3
通讯作者：
Gavaghan DJ
中科院分区：
文献类型：
--
作者：
Mirams GR;Arthurs CJ;Bernabeu MO;Bordas R;Cooper J;Corrias A;Davit Y;Dunn SJ;Fletcher AG;Harvey DG;Marsh ME;Osborne JM;Pathmanathan P;Pitt-Francis J;Southern J;Zemzemi N;Gavaghan DJ
Chaste -癌症，心脏和软组织环境-是一个开源C++库，用于生理学和生物学数学模型的计算模拟。代码开发由两个初始应用驱动：心脏电生理学和癌症发展。大量的心脏电生理学研究已经被启用和执行，包括对真实人类心脏几何形状的除颤的高性能计算研究。已经开发出了肿瘤发生和生长的新模型。特别是，基于细胞的模拟提供了新的见解干细胞在结肠直肠隐窝的作用。贞洁是不断发展的，现在正被应用于更广泛的问题。该代码提供了用于处理常见科学计算组件的模块，例如常微分方程和偏微分方程（ODE/PDE）的网格和求解器。这些组件的重复使用避免了研究人员在每个新项目中“重新发明轮子”的需要，加快了新应用的进展速度。Chaste使用工业衍生技术开发，特别是测试驱动开发，以确保代码质量，重用和可靠性。在这篇文章中，我们提供了一些例子来说明Chaste可以用来解决的问题类型，这些问题可以在桌面计算机上运行。我们强调了一些已经使用或正在使用Chaste的科学研究，以及它们提供的见解。具体发行版和开发版的源代码都可以在开放源代码Berkeley Software Distribution（BSD）许可证下下载，网址为http：//www.cs.ox.ac.uk/chaste，还有邮件列表的详细信息以及文档和教程的链接。
Chaste — Cancer, Heart And Soft Tissue Environment — is an open source C++ library for the computational simulation of mathematical models developed for physiology and biology. Code development has been driven by two initial applications: cardiac electrophysiology and cancer development. A large number of cardiac electrophysiology studies have been enabled and performed, including high-performance computational investigations of defibrillation on realistic human cardiac geometries. New models for the initiation and growth of tumours have been developed. In particular, cell-based simulations have provided novel insight into the role of stem cells in the colorectal crypt. Chaste is constantly evolving and is now being applied to a far wider range of problems. The code provides modules for handling common scientific computing components, such as meshes and solvers for ordinary and partial differential equations (ODEs/PDEs). Re-use of these components avoids the need for researchers to ‘re-invent the wheel’ with each new project, accelerating the rate of progress in new applications. Chaste is developed using industrially-derived techniques, in particular test-driven development, to ensure code quality, re-use and reliability. In this article we provide examples that illustrate the types of problems Chaste can be used to solve, which can be run on a desktop computer. We highlight some scientific studies that have used or are using Chaste, and the insights they have provided. The source code, both for specific releases and the development version, is available to download under an open source Berkeley Software Distribution (BSD) licence at http://www.cs.ox.ac.uk/chaste, together with details of a mailing list and links to documentation and tutorials.
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影响因子：
2.1
作者：
Cickovski, Trevor;Aras, Kedar;Newman, Stuart A.
通讯作者：
Newman, Stuart A.
DOI：
10.1098/rsta.2010.0144
发表时间：
2010-08-28
影响因子：
5
作者：
Cooper, Jonathan;Cervenansky, Frederic;Coveney, Peter V.
通讯作者：
Coveney, Peter V.
影响因子：
2.2
作者：
Beck, K
通讯作者：
Beck, K
影响因子：
2.5
作者：
Corrias, Alberto;Pathmanathan, Pras;Buist, Martin L.
通讯作者：
Buist, Martin L.
科学软件开发不是矛盾的。
影响因子：
4.3
作者：
Baxter, Susan M.;Day, Steven W.;Fetrow, Jacquelyn S.;Reisinger, Stephanie J.
通讯作者：
Reisinger, Stephanie J.