Characterization and peripheral blood biomarker assessment of anti-Jo-1 antibody-positive interstitial lung disease.
Characterization and peripheral blood biomarker assessment of anti-Jo-1 antibody-positive interstitial lung disease.
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DOI：
10.1002/art.24631
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发表时间：
2009-07
影响因子：
--
通讯作者：
Ascherman, Dana P.
中科院分区：
文献类型：
--
作者：
Richards, Thomas J.;Eggebeen, Aaron;Gibson, Kevin;Yousem, Samuel;Fuhrman, Carl;Gochuico, Bernadette R.;Fertig, Noreen;Oddis, Chester V.;Kaminski, Naftali;Rosas, Ivan O.;Ascherman, Dana P.
Combining clinical, radiographic, functional, and serum protein biomarker assessment, this study defines the prevalence and clinical characteristics of ILD in a large cohort of patients possessing anti-Jo-1 antibodies. Clinical records, pulmonary function testing, and imaging studies determined the existence of ILD in anti-Jo-1 antibody positive (anti-Jo-1 Ab+) individuals accumulated in the University of Pittsburgh Myositis Database from 1982–2007. Multiplex ELISA of serum inflammatory markers, cytokines, chemokines, and matrix metalloproteinases in different patient subgroups then permitted assessment of serum proteins associated with anti-Jo-1 Ab+ ILD. Among 90 anti-Jo-1 Ab+ individuals with sufficient clinical, radiographic, and/or pulmonary function data, 77 (86%) met criteria for ILD. While computerized tomography scans revealed a variety of patterns suggestive of underlying UIP or NSIP, review of histopathologic abnormalities in a subset (n=22) of individuals undergoing open lung biopsy demonstrated a preponderance of UIP and DAD. Multiplex ELISA yielded statistically significant associations between Jo-1 Ab+ ILD and elevated serum levels of CRP, CXCL9, and CXCL10 that distinguished this subgroup from IPF and anti-SRP Ab+ myositis. Recursive partitioning further demonstrated that combinations of these and other serum protein biomarkers can distinguish these subgroups with high sensitivity and specificity. In this large cohort of anti-Jo-1 Ab+ individuals, the incidence of ILD approaches 90%. Multiplex ELISA demonstrates disease-specific associations between Jo-1 Ab+ ILD and serum levels of CRP as well as the IFN-γ-inducible chemokines CXCL9 and CXCL10, highlighting the potential of this approach to define biologically active molecules contributing to the pathogenesis of myositis-associated ILD.
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影响因子：
5.5
作者：
Betteridge, Z.;Gunawardena, H.;McHugh, N.
通讯作者：
McHugh, N.
影响因子：
--
作者：
Stone, Kerry B.;Oddis, Chester V.;Ascherman, Dana P.
通讯作者：
Ascherman, Dana P.
影响因子：
--
作者：
Sultan, Shabina M.;Allen, Elizabeth;Isenberg, David A.
通讯作者：
Isenberg, David A.
影响因子：
--
作者：
BENBASSAT, J;GEFEL, D;ZLOTNICK, A
通讯作者：
ZLOTNICK, A
DOI：
10.1002/art.23571
发表时间：
2008-05-15
期刊：
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
影响因子：
--
作者：
Fathi, Maryam;Vikgren, Jenny;Lundberg, Ingrid E.
通讯作者：
Lundberg, Ingrid E.