Reduced sensitivity to immediate reward during decision-making in older than younger adults.
Reduced sensitivity to immediate reward during decision-making in older than younger adults.
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DOI：
10.1371/journal.pone.0036953
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Cohen JD
中科院分区：
文献类型：
--
作者：
Eppinger B;Nystrom LE;Cohen JD
我们研究了老年人与年轻人在决策过程中倾向于立即奖励而不是延迟奖励的程度是否不同。为了检验与年龄相关的延迟折扣差异的神经相关性，我们获得了功能性磁共振图像，同时参与者在较小但较早的和较大的但较晚的金钱奖励之间做出决定。行为结果显示，与年龄相关的延迟折扣减少。老年人不那么冲动的决策与腹侧纹状体对即刻奖励的激活程度较低有关。此外，与年轻人相比，老年人总体上表现出更高的延迟选择比例和背侧纹状体活动减少的比例。这表明老年人背侧纹状体的奖赏敏感度降低。综上所述，我们的发现表明，老年人不那么冲动的决策是由于纹状体区域对奖励的敏感性降低所致。这些与年龄相关的奖赏敏感性变化可能是由于多巴胺能神经调节随着年龄的变化而产生的。
We examined whether older adults differ from younger adults in the degree to which they favor immediate over delayed rewards during decision-making. To examine the neural correlates of age-related differences in delay discounting we acquired functional MR images while participants made decisions between smaller but sooner and larger but later monetary rewards. The behavioral results show age-related reductions in delay discounting. Less impulsive decision-making in older adults was associated with lower ventral striatal activations to immediate reward. Furthermore, older adults showed an overall higher percentage of delayed choices and reduced activity in the dorsal striatum than younger adults. This points to a reduced reward sensitivity of the dorsal striatum in older adults. Taken together, our findings indicate that less impulsive decision-making in older adults is due to a reduced sensitivity of striatal areas to reward. These age-related changes in reward sensitivity may result from transformations in dopaminergic neuromodulation with age.
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影响因子：
5.7
作者：
Ballard K;Knutson B
通讯作者：
Knutson B
影响因子：
25
作者：
Kable, Joseph W.;Glimcher, Paul W.
通讯作者：
Glimcher, Paul W.
影响因子：
5.7
作者：
Christakou, Anastasia;Brammer, Mick;Rubia, Katya
通讯作者：
Rubia, Katya
DOI：
10.1073/pnas.0802127105
发表时间：
2008-09-30
影响因子：
11.1
作者：
Dreher, Jean-Claude;Meyer-Lindenberg, Andreas;Berman, Karen Faith
通讯作者：
Berman, Karen Faith
影响因子：
13.7
作者：
Laibson, D
通讯作者：
Laibson, D