MicroRNAs as biomarker and novel therapeutic target for posttraumatic stress disorder in Veterans.
MicroRNAs as biomarker and novel therapeutic target for posttraumatic stress disorder in Veterans.
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DOI：
10.1016/j.psychres.2021.114252
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发表时间：
2021-11
影响因子：
11.3
通讯作者：
Szabo YZ
中科院分区：
文献类型：
--
作者：
Gupta S;Guleria RS;Szabo YZ
创伤后应激障碍（PTSD）是退伍军人常见的精神障碍，其特征是经历创伤事件后的过度觉醒，侵入性思维，闪回，过度警惕和痛苦。PTSD的一些已知生理效应包括下丘脑-垂体-肾上腺（HPA）轴失衡，这是一种导致神经元缺陷和行为改变的皮质功能。此外，炎症分子的过度释放和免疫系统失调与PTSD的病理生理学有关。由于这种疾病的复杂性，PTSD的生物学基础仍然无法解释。研究新的生物标志物以了解PTSD的发病机制可能反映了治疗用途和治疗的潜在分子网络。循环microRNA（miRNAs）和外来体是不断发展的生物标志物，在包括PTSD在内的精神和神经系统疾病中发挥关键作用。鉴于战斗创伤的独特性质，以及有证据表明，很大一部分退伍军人没有从前线治疗中受益，因此有必要特别关注退伍军人。在本综述中，我们描述了几种miRNA在退伍军人PTSD中的识别和作用。miRNA通过FKBP 5与HPA轴调节的关联，FKBP 5是PTSD中的关键调节剂，被讨论为精神疾病中的新兴分子。我们的结论是，miRNA可用作PTSD退伍军人的循环生物标志物检测。
Posttraumatic stress disorder (PTSD) is a common psychiatric disorder for military Veterans, characterized by hyperarousal, intrusive thoughts, flashbacks, hypervigilance, and distress after experiencing traumatic events. Some of the known physiological effects of PTSD include hypothalamic-pituitary-adrenal (HPA)-axis imbalance, a cortical function resulting in neuronal deficit and changes in behavior. Moreover, excessive discharge of inflammatory molecules and a dysregulated immune system are implicated in the pathophysiology of PTSD. Due to complex nature of this disorder, the biological underpinnings of PTSD remain inexplicable. Investigating novel biomarkers to understanding the pathogenesis of PTSD may reflect the underlying molecular network for therapeutic use and treatment. Circulatory microRNAs (miRNAs) and exosomes are evolving biomarkers that have shown a key role in psychiatric and neurological disorders including PTSD. Given the unique nature of combat trauma, as well as evidence that a large portion of Veterans do not benefit from frontline treatments, focus on veterans specifically is warranted. In the present review, we delineate the identification and role of several miRNAs in PTSD among veterans. An association of miRNA with HPA-axis regulation through FKBP5, a key modulator in PTSD is discussed as an emerging molecule in psychiatric diseases. We conclude that miRNAs may be used as circulatory biomarker detection in Veterans with PTSD.
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影响因子：
120.7
作者：
Binder, Elisabeth B.;Bradley, Rebekah G.;Ressler, Kerry J.
通讯作者：
Ressler, Kerry J.
影响因子：
5.3
作者：
Brites D;Fernandes A
通讯作者：
Fernandes A
影响因子：
10.3
作者：
Asnaani, Anu;Reddy, Madhavi K.;Shea, M. Tracie
通讯作者：
Shea, M. Tracie
DOI：
10.1016/j.pnpbp.2016.03.010
发表时间：
2017-02-06
影响因子：
5.6
作者：
Alural B;Genc S;Haggarty SJ
通讯作者：
Haggarty SJ
DOI：
10.1038/nrm.2015.2
发表时间：
2016-01
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
Dominguez AA;Lim WA;Qi LS
通讯作者：
Qi LS