Association of Circulating Cathepsin S and Cardiovascular Disease Among Patients With Type 2 Diabetes: A Cross-Sectional Community-Based Study.
Association of Circulating Cathepsin S and Cardiovascular Disease Among Patients With Type 2 Diabetes: A Cross-Sectional Community-Based Study.
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2 型糖尿病患者循环组织蛋白酶 S 与心血管疾病的关联：一项基于社区的横断面研究
DOI：
10.3389/fendo.2021.615913
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发表时间：
2021
影响因子：
5.2
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Jing Y;Shi J;Lu B;Zhang W;Yang Y;Wen J;Hu R;Yang Z;Wang X
背景组织蛋白酶S作为一种脂肪因子，在动脉粥样硬化、糖尿病等多种疾病中发挥重要作用。本研究旨在阐明2型糖尿病患者循环组织蛋白酶S与心血管疾病（CVD）的关系。方法采用社区横断面调查方法，对339名2型糖尿病患者进行调查。收集基本信息、医学和实验室数据。ELISA法检测血清组织蛋白酶S水平。结果与CVD（-）组相比，CVD（+）组血清组织蛋白酶S水平显著升高，中位数分别为23.68 ng/ml（18.54-28.02）和26.81 ng/ml（21.19-37.69）（P < 0.001）。急性冠状动脉综合征（ACS）患者血清组织蛋白酶S水平显著高于稳定型心绞痛（SAP）患者，其中位数分别为34.65 ng/ml（24.33-42.83）和25.52 ng/ml（20.53-31.47）（P < 0.01）。斯皮尔曼相关分析显示，循环组织蛋白酶S与几种心血管危险因素相关。单因素和多因素Logistic回归分析显示，在调整潜在混杂因素后，循环组织蛋白酶S是CVD的独立危险因素（均P < 0.001）。限制性三次样条函数分析显示，循环组织蛋白酶S与CVD呈线性相关。受试者工作特征（ROC）曲线分析显示，组织蛋白酶S的曲线下面积（AUC）为0.80（95% CI：0.75-0.84，P < 0.001），组织蛋白酶S的最佳临界值为26.28 ng/ml。结论2型糖尿病中CVD（+）组循环组织蛋白酶S水平明显高于CVD（-）组。血清组织蛋白酶S水平升高与CVD风险增加相关，即使在调整潜在混杂因素后也是如此。因此，组织蛋白酶S可能是一个潜在的诊断CVD的生物标志物。
Background Cathepsin S, as an adipokine, was reported to play a critical role in various disease, including atherosclerosis and diabetes. The present study aims to elucidate the relationship between circulating cathepsin S and cardiovascular disease (CVD) in patients with type 2 diabetes. Methods A total of 339 type 2 diabetes individuals were enrolled in this cross-sectional community-based study. Basic information, medical and laboratory data were collected. Serum cathepsin S levels were assessed by ELISA. Results Compared to the CVD (−) group, levels of serum cathepsin S were significantly higher in the CVD (+) group, with the median 23.68 ng/ml (18.54–28.02) and 26.81 ng/ml (21.19–37.69) respectively (P < 0.001). Moreover, patients with acute coronary syndrome (ACS) had substantially higher levels of serum cathepsin S than those with stable angina pectoris (SAP), with the median 34.65 ng/ml (24.33–42.83) and 25.52 ng/ml (20.53–31.47) respectively (P < 0.01). The spearman correlation analysis showed that circulating cathepsin S was correlated with several cardiovascular risk factors. The univariate and multivariate logistic regression analysis revealed that circulating cathepsin S was an independent risk factor for CVD (all P < 0.001) after adjustment for potential confounders. Restricted cubic spline analysis showed circulating cathepsin S had a linearity association with CVD. In addition, receiver operating characteristic (ROC) curve analysis demonstrated that the area under curve (AUC) values of cathepsin S was 0.80 (95% CI: 0.75–0.84, P < 0.001), with the optimal cutoff value of cathepsin 26.28 ng/ml. Conclusion Circulating cathepsin S was significantly higher in the CVD (+) group than that in the CVD (−) one among type 2 diabetes. The increased serum cathepsin S levels were associated with increased risks of CVD, even after adjusting for potential confounders. Thus, cathepsin S might be a potential diagnostic biomarker for CVD.
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